Citation: Wenjun Yang, Qiaoling Tan, Wenjiao Xie, Xiaoyu Pan, Youyong Yuan. Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments[J]. University Chemistry, ;2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150 shu

Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments

School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China

Corresponding author: Youyong Yuan, yuanyy@scut.edu.cn
Received Date: 22 May 2024
Revised Date: 4 July 2024

Guided by the educational objective of cultivating high-quality applied talents, this paper proposes a comprehensive experimental module that integrates fundamental knowledge and experimental skills from polymer chemistry, biomedical engineering, and instrumental analysis. In this experiment, calcium phosphate is employed as the calcium source for gelation. By precisely controlling the mixing ratio and process of calcium chloride and sodium phosphate solutions, calcium phosphate particles are uniformly dispersed in sodium alginate, a natural polymer. Under stirring, these particles gradually release calcium ions, which react with sodium alginate to form calcium alginate gel particles with micrometer-scale sizes, while achieving efficient drug encapsulation. Dynamic light scattering technique is employed to evaluate particle size and distribution, and fluorescence spectrophotometry is applied to analyze drug encapsulation efficiency and release behavior. This experimental design is based on current research hotspots and utilizes environmentally friendly materials and methods, ensuring its ecological friendliness. Moreover, the experimental model has potential expandability and can be applied to studies of other responsive polymers and drug carriers. The experiment is designed to simultaneously enhance students’ basic experimental skills and advanced research competence, fostering innovative thinking and independent research abilities. Through guidance in an exploratory learning environment, the module aims to nurture innovative talents capable of driving future scientific development
- Calcium alginate,
- Microgel,
- Drug delivery,
- Experimental teaching
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