悟空巧饰磷脂膜，囊泡大败癌细胞

引用本文: 刘书羽, 孙小敏, 宋勃翰, 曾高峰, 杜冰冰, 果崇申, 王琮, 王磊. 悟空巧饰磷脂膜，囊泡大败癌细胞[J]. 大学化学, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113 shu

Citation: Shuyu Liu, Xiaomin Sun, Bohan Song, Gaofeng Zeng, Bingbing Du, Chongshen Guo, Cong Wang, Lei Wang. Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications[J]. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113 shu

悟空巧饰磷脂膜，囊泡大败癌细胞

刘书羽 ^1,2, ,
孙小敏 ^1, ,
宋勃翰 ^1, ,
曾高峰 ^1, ,
杜冰冰 ^1, ,
果崇申 ^1, ,
王琮 ^2, ,
王磊 ^1,

1.
哈尔滨工业大学化工与化学学院, 哈尔滨 150001;
2.
哈尔滨工业大学电信学院, 哈尔滨 150001
基金项目:
国家自然科学基金(52473109,52073071)；黑龙江省自然科学基金优秀青年基金(YQ2022E021)；中央高校基本科研业务费专项资金资助(HIT.DZJJ.2023056)；黑龙江省高等教育教学改革项目(SJGY20210302)

摘要: “我们能人工合成一个细胞吗？Can a cell be artificially synthesized？”——这是2021年《科学》期刊新发布的世界最前沿的125个重大科学问题之一。科学家为了揭示“生命起源”的奥秘以及解决世界关注的重大基础科学问题，设计出人造细胞这类仿生材料。它们最明显的特点就是具有与生物细胞类似的结构与功能。因此，深入研究人造细胞，不仅有利于研究真实细胞的结构与功能机制，还有助于建立非生物物质与真实细胞之间的联系，从而搭建非生命系统与生命系统之间的桥梁，为生命起源等相关研究提供实验与理论依据。而磷脂囊泡作为目前应用最为广泛的人造细胞更是有着广阔的应用前景。为了使“磷脂囊泡”这类材料以及相关研究技术得到更广泛的认识，本文基于耳熟能详的四大名著之一——《西游记》，讲述了孙悟空凭借火眼金睛帮助磷脂囊泡战胜癌细胞的故事，介绍了磷脂囊泡的设计和制备、代表功能以及体内治疗案例，以期促进广大读者对该技术的理解，并激发更多该技术潜在的应用可能。

关键词:

English

Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications

1.
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China;
2.
School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150001, China
Received Date: 17 April 2024
Revised Date: 07 May 2024
Available Online: 19 September 2024

Abstract: “Can a cell be artificially synthesized?” This question stands among the 125 major scientific inquiries highlighted by the journal Science in 2021. To unravel the mysteries of the origin of life and address the fundamental scientific challenges, scientists have developed artificial cells as biomimetic materials mimicking the structure and functions of biological cells. Delving into artificial cells not only aids in understanding cellular mechanisms but also bridges the gap between non-living and living systems, offering insights and foundations for research into the origin of life and related fields. Phospholipid vesicles, particularly widely applied as artificial cells, hold vast potential in biomedical applications. This article, inspired by the classic tale of “Journey to the West”, narrates how phospholipid vesicles, aided by the Monkey King’s keen vision, combat cancer cells. It details the design, preparation, functionalities, and therapeutic applications of phospholipid-vesicle-based artificial cells, aiming to enhance readers’ understanding and stimulate further exploration of this transformative technology.

Key words:

1. [1]
  Feng, B.; Zhou, F.; Lu, W.; Wang, D.; Wang, T.; Luo, C.; Wang, H.; Li, Y.; Yu, H. Biomater. Sci. 2017, 5 (8), 1522.Feng, B.; Zhou, F.; Lu, W.; Wang, D.; Wang, T.; Luo, C.; Wang, H.; Li, Y.; Yu, H. Biomater. Sci. 2017, 5 (8), 1522.
2. [2]
  et al. Science 2010, 328 (5981), 1009.et al. Science 2010, 328 (5981), 1009.
3. [3]
  Peters, R. J.; Marguet, M.; Marais, S.; Fraaije, M. W.; van Hest, J. C.; Lecommandoux, S. Angew. Chem. Int. Edit. 2014, 126 (1), 150.Peters, R. J.; Marguet, M.; Marais, S.; Fraaije, M. W.; van Hest, J. C.; Lecommandoux, S. Angew. Chem. Int. Edit. 2014, 126 (1), 150.
4. [4]
  Kumar, R. K.; Harniman, R. L.; Patil, A. J.; Mann S. Chem. Sci. 2016, 7 (9), 5879.Kumar, R. K.; Harniman, R. L.; Patil, A. J.; Mann S. Chem. Sci. 2016, 7 (9), 5879.
5. [5]
  Wu, H.; Du, X.; Meng, X.; Qiu, D.; Qiao, Y. Nat. Commun. 2021, 12 (1), 6113.Wu, H.; Du, X.; Meng, X.; Qiu, D.; Qiao, Y. Nat. Commun. 2021, 12 (1), 6113.
6. [6]
  Percec, V.; Wilson, D. A.; Leowanawat, P.; Wilson, C. J.; Hughes, A. D.; Kaucher, M. S.; Hammer, D. A.; Levine, D. H.; Kim, A. J.; Bates, F. S.;Percec, V.; Wilson, D. A.; Leowanawat, P.; Wilson, C. J.; Hughes, A. D.; Kaucher, M. S.; Hammer, D. A.; Levine, D. H.; Kim, A. J.; Bates, F. S.;
7. [7]
  Xu, Q.; Zhang, Z.; Lui, P. P. Y.; Lu, L.; Li, X.; Zhang, X. Mater. Today Bio. 2023, 100877.Xu, Q.; Zhang, Z.; Lui, P. P. Y.; Lu, L.; Li, X.; Zhang, X. Mater. Today Bio. 2023, 100877.
8. [8]
  Villar, G.; Graham, A. D.; Bayley, H. A. Science 2013, 340 (6128), 48.Villar, G.; Graham, A. D.; Bayley, H. A. Science 2013, 340 (6128), 48.
9. [9]
  Elani, Y.; Law, R. V.; Ces, O. Nat. Commun. 2014, 5, 5305.Elani, Y.; Law, R. V.; Ces, O. Nat. Commun. 2014, 5, 5305.
10. [10]
  Karlsson, M.; Sott, K.; Davidson, M.; Cans, A. S.; Linderholm, P.; Chiu, D.; Orwar, O. Proc. Natl. Acad. Sci. U. S. A. 2002, 99 (18), 11573.Karlsson, M.; Sott, K.; Davidson, M.; Cans, A. S.; Linderholm, P.; Chiu, D.; Orwar, O. Proc. Natl. Acad. Sci. U. S. A. 2002, 99 (18), 11573.
11. [11]
  Karlsson, A.; Karlsson, R.; Karlsson, M.; Cans, A. S.; Strömberg, A.; Ryttsen, F.; Orwar, O. Nature 2001, 409, 150.Karlsson, A.; Karlsson, R.; Karlsson, M.; Cans, A. S.; Strömberg, A.; Ryttsen, F.; Orwar, O. Nature 2001, 409, 150.
12. [12]
  Rustom, A.; Saffrich, R.; Markovic, I.; Walther, P.; Gerdes, H.-H. Science 2004, 303 (5660), 1007.Rustom, A.; Saffrich, R.; Markovic, I.; Walther, P.; Gerdes, H.-H. Science 2004, 303 (5660), 1007.
13. [13]
  Sott, K.; Lobovkina, T.; Lizana, L.; Tokarz, M.; Bauer, B.; Konkoli, Z.; Orwar, O. Nano Lett. 2006, 6 (2), 209.Sott, K.; Lobovkina, T.; Lizana, L.; Tokarz, M.; Bauer, B.; Konkoli, Z.; Orwar, O. Nano Lett. 2006, 6 (2), 209.
14. [14]
  Davidson, M.; Karlsson, M.; Sinclair, J.; Sott, K.; Orwar, O. J. Am. Chem. Soc. 2003, 125 (2), 374.Davidson, M.; Karlsson, M.; Sinclair, J.; Sott, K.; Orwar, O. J. Am. Chem. Soc. 2003, 125 (2), 374.
15. [15]
  Lentini, R.; Santero, S. P.; Chizzolini, F.; Cecchi, D.; Fontana, J.; Marchioretto, M.; Del. Bianco, C.; Terrell, J. L.; Spencer, A. C.; Martini, L.; et al. Nat. Commun. 2014, 5 (1), 4012.Lentini, R.; Santero, S. P.; Chizzolini, F.; Cecchi, D.; Fontana, J.; Marchioretto, M.; Del. Bianco, C.; Terrell, J. L.; Spencer, A. C.; Martini, L.; et al. Nat. Commun. 2014, 5 (1), 4012.
16. [16]
  高明, 国力, 敖越, 吕秋凤. 沈阳农业大学学报, 2002, No. 4, 315.
17. [17]
  Schwendener, R. A. Ther. Adv. Vaccines Immunother. 2014, 2 (6), 159.Schwendener, R. A. Ther. Adv. Vaccines Immunother. 2014, 2 (6), 159.
18. [18]
  Vahed, S. Z.; Salehi, R.; Davaran, S.; Sharifi, S. Mater. Sci. Eng. C 2017, 71, 1327.Vahed, S. Z.; Salehi, R.; Davaran, S.; Sharifi, S. Mater. Sci. Eng. C 2017, 71, 1327.
19. [19]
  Joffre, O. P.; Segura, E.; Savina, A.; Amigorena, S. Nat. Rev. Immunol. 2012, 12 (8), 557.Joffre, O. P.; Segura, E.; Savina, A.; Amigorena, S. Nat. Rev. Immunol. 2012, 12 (8), 557.
20. [20]
  Koshy, S. T.; Cheung, A. S.; Gu, L.; Graveline, A. R.; Mooney, D. J. Adv. Biosyst. 2017, 1 (1-2), 1600013.Koshy, S. T.; Cheung, A. S.; Gu, L.; Graveline, A. R.; Mooney, D. J. Adv. Biosyst. 2017, 1 (1-2), 1600013.
21. [21]
  Yuba, E. Mol. Immunol. 2018, 98, 8.Yuba, E. Mol. Immunol. 2018, 98, 8.
22. [22]
  姜满乐, 张荡, 张箭, 徐平, 王磊. 大学化学, 2023, 38 (11), 142.
23. [23]
  姚恒美. 竞争情报, 2023, 19 (3), 54.
24. [24]
  Jiang, W.; Wu, Z.; Gao, Z.; Wan, M.; Zhou, M.; Mao, C.; Shen, J. ACS Nano 2022, 16 (10), 15705.Jiang, W.; Wu, Z.; Gao, Z.; Wan, M.; Zhou, M.; Mao, C.; Shen, J. ACS Nano 2022, 16 (10), 15705.
25. [25]
  Mu, W.; Jia, L.; Zhou, M.; Wu, J.; Lin, Y.; Mann, S.; Qiao, Y. Nat. Chem. 2024, 16 (2), 158.Mu, W.; Jia, L.; Zhou, M.; Wu, J.; Lin, Y.; Mann, S.; Qiao, Y. Nat. Chem. 2024, 16 (2), 158.
26. [26]
  Wang, L.; Song, S. D.; van Hest, J.; Abdelmohsen, L. K. E. A.; Huang, X.; Sanchez, S. Small 2020, 16, 1907680.Wang, L.; Song, S. D.; van Hest, J.; Abdelmohsen, L. K. E. A.; Huang, X.; Sanchez, S. Small 2020, 16, 1907680.

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 30
HTML全文浏览量: 3

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

悟空巧饰磷脂膜，囊泡大败癌细胞

English

Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

悟空巧饰磷脂膜，囊泡大败癌细胞

English

Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs