新工科背景下有机化学综合实验改革——以苯佐卡因制备实验的改进研究为例

引用本文: 徐国栋, 盛成才, 赵晓萌, 张拓疆, 刘总堂, 董军. 新工科背景下有机化学综合实验改革——以苯佐卡因制备实验的改进研究为例[J]. 大学化学, 2024, 39(11): 286-295. doi: 10.12461/PKU.DXHX202403094 shu

Citation: Guodong Xu, Chengcai Sheng, Xiaomeng Zhao, Tuojiang Zhang, Zongtang Liu, Jun Dong. Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine[J]. University Chemistry, 2024, 39(11): 286-295. doi: 10.12461/PKU.DXHX202403094 shu

新工科背景下有机化学综合实验改革——以苯佐卡因制备实验的改进研究为例

盐城师范学院化学与环境工程学院, 江苏盐城 224007
基金项目:
江苏省高等学校基础科学(自然科学)面上项目(22KJB150046)；盐城师范学院教育教学改革课题(2023YCTCJGZ07)

摘要: 新工科背景下，化学类专业课程不仅强调培养学生扎实的化学基本功，而且注重多学科交叉融合，培养学生与时俱进、勇于创新的科学精神。“苯佐卡因的制备”是一个经典的有机化学综合性本科教学实验。在原先的反应过程中，酯化反应产生大量废酸，还原反应步骤繁琐，总体反应时间长，缺少趣味性。为了提升该实验的有效时长，加强实验过程的绿色环保性，提升实验的拓展性与探究性，我们通过引入前沿科学成果对该制备反应进行了改进。改进后的实验，在酯化反应步骤使用低共熔溶剂进行催化，可循环使用，绿色环保。在还原反应步骤，则是使用连二硼酸作为还原剂、4,4’-联吡啶作为催化剂，在室温下即可反应，反应温和，颜色变化明显，富有趣味性。该改进实验，不仅可以激发学生的学习兴趣，而且可以提高学生的科研素养，培养学生的绿色化学理念，以及独立思考和分析解决问题的能力。

关键词:

English

Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine

School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, Jiangsu Province, China
Received Date: 26 March 2024
Revised Date: 16 May 2024
Available Online: 03 June 2024

Abstract: In the context of emerging engineering education, chemistry courses emphasize not only the development of students’ solid foundational skills in chemistry but also the integration of multidisciplinary knowledge to foster an innovative scientific spirit. “The Preparation of Benzocaine” is a classic undergraduate experiment in comprehensive organic chemistry. However, the original reaction procedure involves the generation of substantial waste acid during esterification, a cumbersome and time-consuming reduction step, and lacks engagement. To enhance efficiency, environmental friendliness, expansiveness and exploratory nature of the experiment, cutting-edge scientific advancements have been integrated into the preparation reaction. In the improved experiment, a deep eutectic solvent is utilized as a catalyst in the esterification reaction, which is recyclable and environmentally friendly. For the reduction step, tetrahydroxydiboron serves as the reducing agent and 4,4’-bipyridine as the catalyst, enabling the reaction to take place at room temperature with a noticeable color change, thereby making it engaging. This improved experiment not only stimulates students’ interest in learning, but also improves students’ scientific research literacy, and cultivates students’ green chemistry concept, independent thinking, and problem-solving skills.

Key words:

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新工科背景下有机化学综合实验改革——以苯佐卡因制备实验的改进研究为例

English

Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

新工科背景下有机化学综合实验改革——以苯佐卡因制备实验的改进研究为例

English

Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs