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Citation: Guodong Xu, Chengcai Sheng, Xiaomeng Zhao, Tuojiang Zhang, Zongtang Liu, Jun Dong. Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine[J]. University Chemistry, ;2024, 39(11): 286-295. doi: 10.12461/PKU.DXHX202403094 shu

Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine

School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, Jiangsu Province, China

Received Date: 26 March 2024
Revised Date: 16 May 2024

In the context of emerging engineering education, chemistry courses emphasize not only the development of students’ solid foundational skills in chemistry but also the integration of multidisciplinary knowledge to foster an innovative scientific spirit. “The Preparation of Benzocaine” is a classic undergraduate experiment in comprehensive organic chemistry. However, the original reaction procedure involves the generation of substantial waste acid during esterification, a cumbersome and time-consuming reduction step, and lacks engagement. To enhance efficiency, environmental friendliness, expansiveness and exploratory nature of the experiment, cutting-edge scientific advancements have been integrated into the preparation reaction. In the improved experiment, a deep eutectic solvent is utilized as a catalyst in the esterification reaction, which is recyclable and environmentally friendly. For the reduction step, tetrahydroxydiboron serves as the reducing agent and 4,4’-bipyridine as the catalyst, enabling the reaction to take place at room temperature with a noticeable color change, thereby making it engaging. This improved experiment not only stimulates students’ interest in learning, but also improves students’ scientific research literacy, and cultivates students’ green chemistry concept, independent thinking, and problem-solving skills.
- Esterification,
- Deep eutectic solvents,
- Reduction,
- Tetrahydroxydiboron
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