Abstract: This study aims to enhance the connection between laboratory safety and student competency while improving the effectiveness of graduate courses on laboratory safety management standards and training. We propose a case-based teaching method centered on laboratory safety knowledge education. Through a comprehensive analysis of the current state of laboratory safety management course instruction, we introduce several practical reform strategies, including enhancing professional relevance, enriching case content, integrating theory with practice, replicating and deepening knowledge, reforming assessment methods, and emphasizing the evaluation of teaching effectiveness. By organically integrating representative cases with course content, case teaching can become more aligned with practical teaching and student experiences. Utilizing a flipped classroom approach, educators can effectively guide students in perceiving, experiencing, and reflecting on safety concepts through implicit teaching methods, thereby fostering the development of sound safety values among students. Accompanying the reforms in teaching and assessment methods, we aim to implement practical education, creating a comprehensive and multidimensional framework for “Laboratory Safety Management Standards and Training” that facilitates case development and instructional practices, ultimately resulting in a practical, effective, and easily replicable teaching model.