科研新成果助力提升天然产物化学实验课程的高阶性——以盐酸小檗碱在光动力抑菌薄膜中的应用为例

引用本文: 王立娟, 宁语苹, 李坚, 罗沙, 罗雄飞, 王睿文. 科研新成果助力提升天然产物化学实验课程的高阶性——以盐酸小檗碱在光动力抑菌薄膜中的应用为例[J]. 大学化学, 2024, 39(11): 241-250. doi: 10.12461/PKU.DXHX202403017 shu

Citation: Lijuan Wang, Yuping Ning, Jian Li, Sha Luo, Xiongfei Luo, Ruiwen Wang. Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films[J]. University Chemistry, 2024, 39(11): 241-250. doi: 10.12461/PKU.DXHX202403017 shu

科研新成果助力提升天然产物化学实验课程的高阶性——以盐酸小檗碱在光动力抑菌薄膜中的应用为例

东北林业大学材料科学与工程与学院, 哈尔滨 150040
基金项目:
东北林业大学教育教学改革项目(DGY2022-14)

摘要: 天然产物化学实验是基于理论课基础上的一门重要实践课程，以验证为主的实验课缺少高阶性，不利于学生综合能力的提升。因此，通过将科研新成果融入课程的综合实验设计，融入“双碳”理念，强化课程的“两性一度”。该实验将高荧光强度的光动力抑菌食品包装膜的前沿研究融入到天然产物化学实验中，首次将天然聚集诱导发光剂盐酸小檗碱与植酸结合成盐加入到食品包装膜中，构建了一种具有高荧光强度的光动力抑菌膜。本实验融合了天然产物化学、聚集诱导发光和食品微生物学的内容，并推动学生熟悉原理-实验-表征-分析的科研流程，实质性丰富学生的综合知识，强化学生实践能力和创新意识，助力林产化工专业拔尖人才的培养。

关键词:

English

Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films

Materials Science and Engineering, Northeast Forestry University, Harbin 150040, China
Received Date: 05 March 2024
Revised Date: 20 May 2024
Available Online: 22 May 2024

Abstract: Natural products chemistry experiment courses are vital practical part built upon theoretical foundations. However, these verification-focused experiments lack depth and hinder the development of students’ comprehensive abilities. To address this issue, we proposed integrating new scientific research findings into the design of comprehensive experiments, incorporating the concept of “double carbon”, and enhancing the depth of the course. In this experiment, we introduced cutting-edge research on photodynamic antimicrobial food packaging films with high fluorescence intensity into natural product chemistry experiments. Specifically, we incorporated berberine hydrochloride, a naturally occurring aggregation-induced emission agent, with phytic acid to create a salt that was added to the food packaging film, resulting in a photodynamic antimicrobial film with strong fluorescence. This experiment combined the fields of natural product chemistry, aggregation-induced emission, and food microbiology, and encouraged students to become familiar with the research process of theory-experiment-characterization-analysis. Through this integration, students could enrich their comprehensive knowledge, strengthen their practical skills, and foster their innovation consciousness, thus contributing to the cultivation of top talents in the field of forest chemical industry.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

科研新成果助力提升天然产物化学实验课程的高阶性——以盐酸小檗碱在光动力抑菌薄膜中的应用为例

English

Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

科研新成果助力提升天然产物化学实验课程的高阶性——以盐酸小檗碱在光动力抑菌薄膜中的应用为例

English

Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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