Citation: CHEN Lin, MIN Man, LIN Jidi. Synthesis and Antioxidation Activity of 3-Amino-7, 8-dimethoxycoumarin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, ;2020, 37(12): 1420-1425. doi: 10.11944/j.issn.1000-0518.2020.12.200090 shu

Synthesis and Antioxidation Activity of 3-Amino-7, 8-dimethoxycoumarin and Its Derivatives

CHEN Lin ^a,, ,
MIN Man ^b ,
LIN Jidi ^a

a.
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
b.
Guangzhou Huibiao Testing Technology Center, Guangzhou 510670, China

Corresponding author: CHEN Lin, chenlin128@126.com
Received Date: 25 March 2020
Revised Date: 21 July 2020
Accepted Date: 18 August 2020

Fund Project: Supported by the Science and Technology Planning Project of Guangdong Province, China(No.2012b061700040) and the Medical Science and Technology Research Fund Project of Guangdong Province(No.201618171249486)the Science and Technology Planning Project of Guangdong Province, China 2012b061700040the Medical Science and Technology Research Fund Project of Guangdong Province 201618171249486

Figures(2)

Eleven coumarin compounds with aromatic amide skeletons were synthesized. The antioxidant activities of the synthesized compounds were investigated by quenching 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), 2, 2'-azinobis(3-ethylbenzothiazoline-6-sulphonate) ammonium salt cationic radical (ABTS^+·) and hydroxyl radicals. The results show that the scavenging ability of compound 2b to DPPH radicals and hydroxyl radicals is beyond or close to that of the control vitamin C, while the antioxidant activity of derivatives 2a, 2b and 2c is better than that of the parent. Therefore, acylation is a promising way to improve the antioxidant capacity of 3-amino-7, 8-dimethoxycoumarin, especially the scavenging capacity of hydroxyl radicals.
- 3-amino-7, 8-dimethoxycoumarins,
- synthesis,
- antioxidation
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