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Citation: QI Yanxin, HUANG Yubin, JIN Ningyi. Preparation and Release Behavior of Progesterone Nano Micelles in Vitro[J]. Chinese Journal of Applied Chemistry, ;2020, 37(11): 1340-1342. doi: 10.11944/j.issn.1000-0518.2020.11.200239 shu

Preparation and Release Behavior of Progesterone Nano Micelles in Vitro

QI Yanxin ^a,b ,
HUANG Yubin ^b,, ,
JIN Ningyi ^a,c,,

a.
Medical College, Yanbian University, Yanji, Jilin 133002, China
b.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
c.
Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Changchun 130112, China

Corresponding author: HUANG Yubin, ybhuang@ciac.ac.cn JIN Ningyi, ningyik@126.com
Received Date: 10 August 2020
Revised Date: 25 August 2020
Accepted Date: 18 September 2020

Fund Project: Supported by the National Natural Science Foundation of China(No.51673188, No.51903233, No.21975246)the National Natural Science Foundation of China 21975246the National Natural Science Foundation of China 51673188the National Natural Science Foundation of China 51903233

Figures(3)

To prepare new controlled-release progesterone nano micelles, polyethylene glycol-polypropylene glycidyl ether polymer (PEG-PAGE), a diblock degradable polymer carrier, micelles carring progesterone were assembled in water. The drug load and encapsulation ratio under different conditions were investigated and the optimal proportion was selected for the in vitro release study. The results show that the micelles can carry progesterone with a drug load of 4.26% and the encapsulation efficiency of 21.30%. The nano micelles can effectively prolong the release of progesterone. This research is an experimental and technical reference for the development of similar dosage forms of steroid hormones.
- polymer,
- polyethylene glycol-polypropylene glycidyl ether,
- progesterone,
- micellar
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