Citation: MO Yanhong, LI Hui, WANG Bin, XU Xiaohui, LIU Sisi, ZENG Dongdong. Research on the Enhanced Activity of Hemin/G-Quadruplex DNAzyme and Its Application in Biosensors[J]. Chinese Journal of Applied Chemistry, ;2020, 37(11): 1249-1261. doi: 10.11944/j.issn.1000-0518.2020.11.200153 shu

Research on the Enhanced Activity of Hemin/G-Quadruplex DNAzyme and Its Application in Biosensors

MO Yanhong ^a,b ,
LI Hui ^b ,
WANG Bin ^b ,
XU Xiaohui ^b ,
LIU Sisi ^b ,
ZENG Dongdong ^b,,

a.
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
b.
Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

Corresponding author: ZENG Dongdong, zengdd@sumhs.edu.cn
Received Date: 21 May 2020
Revised Date: 19 June 2020
Accepted Date: 8 July 2020

Fund Project: Shanghai Natural Science Foundation 19ZR1474300Supported by Shanghai Natural Science Foundation(No.19ZR1474300) and Shanghai Key Laboratory of Molecular Imaging Project(No.18DZ2260400)Shanghai Key Laboratory of Molecular Imaging Project 18DZ2260400

Figures(5)

Hemin/G-quadruplex DNAzyme is a type of DNA molecule with peroxidase-like activity. Because of its excellent activity, easy modification and programmability, it has been widely used in biosensors and other fields. This article first briefly introduces the structure of G-quadruplex, and then reviews the strategies for enhancing hemin/G-quadruplex DNAzyme activity and application of biosensors based on hemin/G-quadruplex DNAzyme in the detection of biomarkers, microorganisms, biotoxins and metal ions. We also prospect the development trend of hemin/G-quadruplex DNAzyme.
- hemin/G-quadruplex,
- dnazyme,
- peroxidase,
- biosensor
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