Citation: HAN Xiu, KANG Chuanqing. Advances in Synthetic Methods of (R)-α-Lipoic Acid[J]. Chinese Journal of Applied Chemistry, ;2020, 37(11): 1236-1248. doi: 10.11944/j.issn.1000-0518.2020.11.200151 shu

Advances in Synthetic Methods of (R)-α-Lipoic Acid

HAN Xiu ^a ,
KANG Chuanqing ^b,,

a.
College of Chemistry, Sichuan University, Chengdu 610000, China
b.
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: KANG Chuanqing, kangcq@ciac.ac.cn
Received Date: 19 May 2020
Revised Date: 28 June 2020
Accepted Date: 23 July 2020

Figures(18)

The methods for the effective synthesis of (R)-α-lipoic acid have been widely investigated since (R)-α-lipoic acid can be widely used for the treatment of diabetes and diabetic complications. It is also extensively used in health care products. Therefore, asymmetric synthesis of (R)-α-lipoic acid has attracted broad interests from the community of both academia and industry. To date, the reported routes for the synthesis of (R)-α-lipoic acid include asymmetric synthesis catalyzed by the enzymatic and chemical catalysts, chiral resolution, and chiral substrate-controlled synthesis. Based on this classification, this paper summarizes the advances of the methods for asymmetric synthesis of (R)-α-lipoic acid and predicts future prospects.
- lipoic acids,
- chiral resolution,
- asymmetric synthesis
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