Citation: LI Di, SUN Jianqiang, XU Bingsong, CHEN Hao, ZHOU Le, HU Lei, WANG Hui. Design and Synthesis of Chalcone-Based Derivative for Sensing Cu(Ⅱ) Ion[J]. Chinese Journal of Applied Chemistry, ;2020, 37(11): 1268-1275. doi: 10.11944/j.issn.1000-0518.2020.11.200120 shu

Design and Synthesis of Chalcone-Based Derivative for Sensing Cu(Ⅱ) Ion

College of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, China

Corresponding author: HU Lei, hulei@wnmc.edu.cn WANG Hui, wanghias@126.com
Received Date: 25 April 2020
Revised Date: 16 June 2020
Accepted Date: 6 July 2020

Fund Project: Anhui Provincial Natural Science Foundation 1908085QB50Supported by Anhui Provincial Natural Science Foundation(No.1908085QB50), and the Training Program of Innovation and Entrepreneurship Education for College Students in Anhui Province(No.S201910368079)the Training Program of Innovation and Entrepreneurship Education for College Students in Anhui Province S201910368079

Figures(11)

A novel chalcone derivative (E)-3-(1-butyl-1H-indol-3-yl)-1-(pyridin-2-yl)prop-2-en -1-one (L) was designed and synthesized from 1-butyl-1H-indole-3-carbaldehyde and 1-(pyridin-2-yl)ethan-1-one by condensation reaction. Compound L was characterized by nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS) and Fourier transform infrared (FT-IR) spectrometry. It is found that probe L exhibits a specific selectivity and high sensitivity to Cu²⁺ with a limit of detection (LOD) at 27.8 nmol/L, giving a noticeable color change from light yellow to red, which demonstrates that probe L can be used to recognize Cu²⁺ by "naked-eye". Probe L binds to Cu²⁺ by a 1:1 stoichiometry. The mechanism for sensing Cu²⁺ was investigated using ¹H NMR titration and theoretical calculations.
- Cu²⁺ probe,
- chalcone derivatives,
- theoretical calculations
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