Citation: CHEN Chen, RUAN Hongli, LÜ Le, SONG Zhixi, LÜ Chengwei, AN Yue. Synthesis of Pyridazine Derivatives by Base-Catalyzed Three-Component Reaction of Aldehyde, Malononitrile and Phthalhydrazide[J]. Chinese Journal of Applied Chemistry, ;2020, 37(5): 502-511. doi: 10.11944/j.issn.1000-0518.2020.05.190311 shu

Synthesis of Pyridazine Derivatives by Base-Catalyzed Three-Component Reaction of Aldehyde, Malononitrile and Phthalhydrazide

College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China

Corresponding author: LÜ Chengwei, chengweilv@126.com
Received Date: 19 November 2019
Revised Date: 6 January 2020
Accepted Date: 20 February 2020

Fund Project: the Department of Science and Technology of Liaoning Province 2019-ZD-0470the Department of Science and Technology of Liaoning Province 2019-MS-215Supported by the Department of Science and Technology of Liaoning Province(No.2019-MS-215, No.2019-ZD-0470)

Figures(3)

Catalytic amount of organic base triethylamine (Et₃N) or inorganic base dipotassium hydrogen phosphate (K₂HPO₄·3H₂O) is proved to effectively promote the three components reaction of aromatic aldehyde, malononitrile and phthalhydrazide under conventional heating conditions. As expected, introduction of water is favorable to the reaction. A series of 1H-pyrazole [1, 2-b]pyridazine-5, 10-diones derivatives was synthesized in the yield of 39%~97%. Both catalysts are soluble in water, and introduction of water also facilitate the separation of the catalyst after reaction. This approach also has advantages of mild reaction conditions, green environmental protection, simple operation and convenient post-treatment.
- trimethylamine,
- dipotassium hydrogen phosphate trihydrate,
- base catalytic,
- multi-component reactions,
- phthalazines derivatives
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