Citation: GUO Hui, YIN Yuanyuan, ZHANG Xueying, ZHUANG Yuwei, JIAN Cao, ZHANG Guobao. Synthesis of N-Cyanoethyl-N-hydroxyethylaniline Catalyzed by Acdic Ionic Liquid[J]. Chinese Journal of Applied Chemistry, ;2020, 37(5): 512-517. doi: 10.11944/j.issn.1000-0518.2020.05.190287 shu

Synthesis of N-Cyanoethyl-N-hydroxyethylaniline Catalyzed by Acdic Ionic Liquid

High & New Technology Research Center of Henan Academy of Sciences, Zhengzhou 450002, China

Corresponding author: GUO Hui, gh3324@163.com ZHANG Guobao, xiehuwangzi@163.com
Received Date: 25 October 2019
Revised Date: 26 December 2019
Accepted Date: 20 February 2020

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N-Cyanoethyl-N-hydroxyethylaniline is an important dye intermediate with a wide range of applications. A green and efficient protocol for the synthesis of N-cyanoethyl-N-hydroxyethylaniline by reaction of acrylonitrile and N-hydroxyethyl aniline with 1-butyl-3-methylimidazolium hydrosulphates ionic liquid ([Bmim]HSO₄) as the catalyst has been developed, eliminating the inert-gas welding and complex operation of traditional methods. The effect of ionic liquid, the amount of ionic liquid, the ratio of substrates, temperature and time were investigated. The optimum reaction conditions were obtained as follow:[BMIM]HSO₄ 0.8 mmol, n(N-hydroxyethyl aniline):n(acrylonitrile)=1:1.2, reaction time of 12 h, reaction temperature of 90 ℃. The acdic ionic liquid could be easily separated and reused for at least 5 times without significantly decrease in catalytic activity.
- acdic ionic liquid,
- N-cyanoethyl-N-hydroxyethylaniline,
- acrylonitrile,
- N-hydroxyethyl aniline
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