Citation: ZHANG Jidong, LI Jiayuan, JIN Huafeng. Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect[J]. Chinese Journal of Applied Chemistry, ;2019, 36(7): 733-748. doi: 10.11944/j.issn.1000-0518.2019.07.190040 shu

Research Progress on Small Molecule Anticancer Drug Release System Based on Fluorescence Effect

School of Chemistry & Chemical Engineering, Ankang Univerisity, Ankang, Shannxi 725000, China

Corresponding author: ZHANG Jidong, akuzjd@aku.edu.cn
Received Date: 18 February 2019
Revised Date: 9 April 2019
Accepted Date: 30 April 2019

Fund Project: Scientific Research Foundation for Advanced Talents of Ankang University 2018AYQDZR06Supported by the Key Projects of Shaanxi Provincial Science & Technology Department(No.2018PT-31), Major Scientific Research Projects of the Leading Industry of Ankang City(No.2016AKZDCY002), Scientific Research Foundation for Advanced Talents of Ankang University(No.2018AYQDZR06), Key Laboratory of Se-Enriched Products Development and Quality Control, Ministry of Agriculture(No.Se-2018B02), the Shaanxi Provincial Innovation Experiment Program for University Students(No.201839032)the Key Projects of Shaanxi Provincial Science & Technology Department 2018PT-31Key Laboratory of Se-Enriched Products Development and Quality Control, Ministry of Agriculture Se-2018B02the Shaanxi Provincial Innovation Experiment Program for University Students 201839032Major Scientific Research Projects of the Leading Industry of Ankang City 2016AKZDCY002

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In recent years, with the rising incidence of cancer, the renewal and development of cancer therapy technology is particularly important. Especially, the introduction of chemotherapy has promoted the research for the release system of fluorescence small molecule anticancer drugs. An anticancer drug release system combines organic fluorescent molecules with anticancer drugs based on fluorescent effect, which has the characteristics of low toxicity, excellent targeting to cancer cells and convenience to track and monitor. Therefore, design of prodrugs with different properties can be used to study the kinetic process of the release of anticancer drugs and provide a powerful tool for the accurate treatment for cancers. This paper mainly introduces the research progress of prodrugs based on camptothecin, SN-38 and adriamycin, and the prospects for their development.
- drug release,
- chemotherapy,
- cancer treatment,
- camptothecin,
- fluorescence small molecular
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