Citation: ZHOU Kai, WENG Ying, HOU Qingqing, LOU Benyong. Preparation, Crystal Structure and Solubility of Organic Salt Hydrate of Berberine-Genistein[J]. Chinese Journal of Applied Chemistry, ;2019, 36(2): 230-235. doi: 10.11944/j.issn.1000-0518.2019.02.180163 shu

Preparation, Crystal Structure and Solubility of Organic Salt Hydrate of Berberine-Genistein

Department of Chemical Engineering and Materials, Ocean College, Minjiang University, Fuzhou 350108, China

Corresponding author: LOU Benyong, lby@mju.edu.cn
Received Date: 9 May 2018
Revised Date: 20 June 2018
Accepted Date: 14 August 2018

Fund Project: the National Undergraduate Innovative Training Program 201610395010Supported by the National Undergraduate Innovative Training Program(No.201610395010), the Natural Science Foundation of Fujian Province(No.2015J01599)the Natural Science Foundation of Fujian Province 2015J01599

Figures(6)

The organic salt hydrate of berberine with genistein, [C₂₀H₁₈NO₄]⁺·[C₁₅H₉O₅]^-·2.5H₂O·0.5(C₂H₅OH), was prepared and its crystal structure was determined. The result showed that the organic salt hydrate crystallized in monoclinic crystal system and P2₁/c space group. The 7-substituted hydroxyl of genistein lost its proton and turned to be anion. The resulting hydroxyl anion was involved in O—H····O^- hydrogen bonding with 4'-substituted hydroxyl, which gave rise to an one-dimensional hydrogen-bonded chain-like structure. Two water molecules formed a chain-like structure through hydrogen-bonding interactions and further connected the 1D chain of genistein into a 2D hydrogen-bonded network. The hydrate turned to be amorphous form after losing water molecules by heating. The amorphous form could transform into crystalline organic salt hydrate after suspending in ethanol-water for 24 h. After forming berberine-genistein salt hydrate, the solubility of genistein in water increased slightly.
- berberine,
- genistein,
- organic salt,
- hydrate,
- hydrogen-bonding
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