Citation: YU Chang, SHAO Shuai, LI Hejie, LIU Guofeng, DING Binbin, MA Ping'an, LIN Jun. Upconversion Nanoparticles Decorated with Hybridization Chain Reaction DNA for Near-infrared Light Controlled Release Doxorubicin[J]. Chinese Journal of Applied Chemistry, ;2018, 35(12): 1485-1491. doi: 10.11944/j.issn.1000-0518.2018.12.180064 shu

Upconversion Nanoparticles Decorated with Hybridization Chain Reaction DNA for Near-infrared Light Controlled Release Doxorubicin

YU Chang ^a,b ,
SHAO Shuai ^a,c ,
LI Hejie ^d ,
LIU Guofeng ^a,e ,
DING Binbin ^a,f ,
MA Ping'an ^a,, ,
LIN Jun ^a,,

a.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China
d.
Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital of Jilin University, Changchun 130041, China
e.
College of Physics, Jilin University, Changchun 130012, China
f.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: MA Ping'an, mapa675@ciac.ac.cn LIN Jun, jlin@ciac.ac.cn
Received Date: 9 March 2018
Revised Date: 14 March 2018
Accepted Date: 2 May 2018

Fund Project: the National Natural Science Foundation of China 21521092the National Natural Science Foundation of China 51628201the Key Research Program of Frontier Sciences, CAS YZDY-SSW-JSC018the National Natural Science Foundation of China NSFC51672268the National Natural Science Foundation of China 51472233Supported by the National Natural Science Foundation of China(No.NSFC51672268, No.51472233, No.51332008, No.51720105015, No.51628201, No.21521092), the Key Research Program of Frontier Sciences, CAS(No.YZDY-SSW-JSC018), Projects for Science and Technology Development Plan of Jilin Province(No.20170101188JC, No.20170414003GH)the National Natural Science Foundation of China 51332008Projects for Science and Technology Development Plan of Jilin Province 20170101188JCProjects for Science and Technology Development Plan of Jilin Province 20170414003GHthe National Natural Science Foundation of China 51720105015

Figures(5)

Nanotechnology has allowed various coatings and modifications to nanostructures for applications of biomedicine. The constructions of simple, economical, controllable and biocompatible drug delivery systems(DDS) are still in demand. Here, we report a NaYF₄:Yb/Tm nanoparticle-based DDS that anticancer drug doxorubicin(Dox) could be quantitatively carried by double stranded DNA thereon that self-assembled through a hybridization chain reaction(HCR). The HCR DNA was absorbed on the surface of upconversion nanoparticles(UCNPs) through linkage to photocleavable 1-(4, 5-dimethoxy-2-nitrophenyl) diazoethane(DMNPE) molecules, which can be cleaved by near ultraviolet light emitted by UCNPs under 980 nm laser light excitation. The controllable release of model drug Dox by near-infrared(NIR) should facilitate selective cytotoxicity to target region and reduced side effects and could prove promising in biomedical applications.
- upconversion nanoparticles,
- DNA hybridization chain reaction,
- controllable release,
- doxorubicin hydrochloride
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