Citation: LI Yuanxiang, LIU Yilin, LEI Sufang, CHEN Dizhao, BO Rui, LI Sunyong. Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1, 2, 3-triazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2018, 35(11): 1325-1330. doi: 10.11944/j.issn.1000-0518.2018.11.170421 shu

Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1, 2, 3-triazole Derivatives

LI Yuanxiang ^a,b,c,, ,
LIU Yilin ^a,b ,
LEI Sufang ^a ,
CHEN Dizhao ^a,c ,
BO Rui ^a ,
LI Sunyong ^a

a.
College of Chemistry and Materials Engineering, Huaihua University, Huaihua, Hu'nan 418008, China
b.
Institute of Organic Synthesis, Huaihua University, Huaihua, Hu'nan 418008, China
c.
Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material, Huaihua University, Huaihua, Hu'nan 418008, China

Corresponding author: LI Yuanxiang, hhxyliyuanjun@163.com
Received Date: 22 November 2017
Revised Date: 23 January 2018
Accepted Date: 7 February 2018

Fund Project: the Scientific Research Fund of the Hu′nan Provincial Education Department 16A165the Open Fund Project of Hu′nan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material HGY201605the Natural Science Foundation of Hu′nan Province 2016JJ4072Supported by the Natural Science Foundation of Hu′nan Province(No.2016JJ4072), the Scientific Research Fund of the Hu′nan Provincial Education Department(No.16A165), the Open Fund Project of Hu′nan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material(No.HGY201605), the Construct Program of the Key Discipline in Huaihua University

Figures(2)

1, 2, 3-Triazole compounds show a wide range of biological activities. In order to find new compounds with bactericidal activity, a series of 2-substituted-4-aryl-2H-1, 2, 3-triazoles was synthesized from benzaldehyde or substituted benzaldehyde, nitromethane and sodium azide in 51% to 91% yields. The structures of these compounds were characterized by nuclear magnetic resonance spectroscopy (NMR), mass spectra and elemental analyses. Most of these compounds show the preliminary antibacterial activity against Gibberella zeae and Phytophythora capsici in vitro, in 25 mg/L concentration. Among them, compound 3a shows 80.4% activity of against Gibberella zeae, compound 3b shows 78.2% activity of against Botrytis cinerea, compounds 3a and 3h show 70.3%, 75.9% activities of against Sclerotonia sclerotiorum, respectively.
- triazole,
- structure characterization,
- fungicidal activity
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