Citation: LI Fei, MAO Shengxue, SUN Yue, LÜ Chengwei, AN Yue. Dipotassium Hydrogenphosphate Assisted Multi-component One-Pot Synthesis of 1, 4-Hihydropyrano[2, 3-c]pyrazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2018, 35(10): 1201-1207. doi: 10.11944/j.issn.1000-0518.2018.10.170393 shu

Dipotassium Hydrogenphosphate Assisted Multi-component One-Pot Synthesis of 1, 4-Hihydropyrano[2, 3-c]pyrazole Derivatives

School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China

Corresponding author: LÜ Chengwei, chengweilv@126.com
Received Date: 2 November 2017
Revised Date: 8 December 2017
Accepted Date: 15 December 2017

Fund Project: Liaoning Province, the Doctoral Scientific Research Foundation 20141100Supported by the National Natural Science Foundation of China(No.21403100), Liaoning Province, the Doctoral Scientific Research Foundation(No.20141100), the Key Laboratory of Education Department of Liaoning Province(No.L201683656)the National Natural Science Foundation of China 21403100the Key Laboratory of Education Department of Liaoning Province L201683656

Figures(1)

Catalytic one-pot four-component reaction is an ideal strategy for efficient and facile synthesis of pyrano[2, 3-c]pyrazoles. The efficacy of dipotassium hydrogenphosphate(K₂HPO₄·3H₂O) as a cheap and readily accessible catalyst for the synthesis of 1, 4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile derivatives via one-pot four-component reaction of ethyl acetoacetate, hydrazine hydrate, aryl aldehydes, and malononitrile was described in this paper. These multi-component condensations proceeded smoothly in aqueous polyethylene glycol(PEG-200) and the corresponding products were obtained in 88%~98% yields. This improved protocol eliminates the problems associated with expensive complex catalyst and tedious purification procedures.
- dipotassium hydrogenphosphate,
- 1, 4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile,
- multi-component reaction,
- synthesis,
- aqueous polyethylene glycol 200
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沈阳化工大学材料科学与工程学院沈阳 110142