Citation: LING Huiping, CHEN Xiaoqing, XIE Shengnan, CHEN Yuejian, SHE Zhigang, LIN Yongcheng, TAO Yiwen. Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity[J]. Chinese Journal of Applied Chemistry, ;2018, 35(6): 708-713. doi: 10.11944/j.issn.1000-0518.2018.06.170281 shu

Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity

a.
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
b.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: TAO Yiwen, yywentao@aliyun.com
Received Date: 10 August 2017
Revised Date: 8 November 2017
Accepted Date: 29 November 2017

Fund Project: the Natural Science Program of Guangdong Province 2016A030313588Supported by the Natural Science Program of Guangdong Province(No.2016A030313588), the Education Bureau Project of Guangzhou City(No.1201610155), the Projects of Guangdong Oceanic and Fishery Administration in 2017(No.A201701C07), the Open-Laboratory Project of Guangzhou Medical University in 2018the Projects of Guangdong Oceanic and Fishery Administration in 2017 A201701C07the Education Bureau Project of Guangzhou City 1201610155

Figures(2)

In order to study the secondary metabolites of dihydroisocoumarin compounds from mangrove endophytic fungi Fusarium sp. F67 and B42, the metabolites of strains F67 and B42 were isolated and purified by chromatographic techniques, and their structures were determined as follows:3, 6, 8-trihydroxy-3, 4, 5, 7-tetramethyl-3, 4-dihydroisocoumarin(sclerotinin A)(1), dihydrocitrinone(2), 5-methylmellein(3), 5-carboxymellein(4), 4-hydroxymellein(5) and mellein(6). Antibacterial activities of compounds 1~4 in 1.0 g/L show that the inhibitory zone against the tested strains ranges from 5.1 to 11.0 mm. Among them, compound 4 has the strongest antibacterial activities and the broadest bacteriostatic spectra. These results provide supplement to the research and development of new antibacterial drug.
- Rhizophora apiculata,
- endophytic fungi,
- dihydroisocoumarins,
- antibacterial activity
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