Citation: JIANG Ya'nan, TANG Lijun, BIAN Yanjiang, ZHONG Keli, HOU Shuhua. A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition[J]. Chinese Journal of Applied Chemistry, ;2017, 34(12): 1462-1467. doi: 10.11944/j.issn.1000-0518.2017.12.170316 shu

A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition

College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning 121013, China

Corresponding author: TANG Lijun, ljtang@bhu.edu.cn
Received Date: 4 September 2017
Revised Date: 19 September 2017
Accepted Date: 28 September 2017

Fund Project: the National Natural Science Foundation of China U1608222Program for Liaoning Excellent Talents in University LR2015001Supported by the National Natural Science Foundation of China(No.21476029, No.U1608222), Program for Liaoning Excellent Talents in University(No.LR2015001)the National Natural Science Foundation of China 21476029

Figures(7)

Hypochlorite(ClO^-) displays essential roles in human immune system, the detection of which has aroused extensive attention. Herein, a hydrazone type fluorescent probe(HEMQ) that containing quinazolinone skeleton was designed and synthesized, and the structure of HEMQ was characterized by ¹H NMR, ¹³C NMR, and HRMS analysis. In V(ethanol):V(water)=1:1(c(PBS)=0.02 mol/L, pH=8.7) solution, probe HEMQ exhibits rapid response and good selectivity toward ClO^- through distinct fluorescence quenching. HEMQ displays good sensitivity to ClO^- with a detection limit of 1.0×10^-4 mol/L. In addition, ClO^- can induce a color change from yellow to colorless of the probe solution, thus, probe HEMQ can act as a colorimetric and florescent dual-channel ClO^- probe.
- quinazolinone,
- fluorescent probe,
- hypochlorite,
- recognition
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