Citation: BU Lulu, WANG Qing, XIE Yongshu. Research Progress of Fluorescent Zinc Probes[J]. Chinese Journal of Applied Chemistry, ;2017, 34(12): 1355-1369. doi: 10.11944/j.issn.1000-0518.2017.12.170302 shu

Research Progress of Fluorescent Zinc Probes

Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: XIE Yongshu, yshxie@ecust.edu.cn
Received Date: 29 August 2017
Revised Date: 7 October 2017
Accepted Date: 9 October 2017

Fund Project: the Central University Basic Research Fellowship 222201714013the Shanghai Oriental Scholar Distinguished Professor Project GZ2016006the National Natural Science Fundation of China 21472047the Central University Basic Research Fellowship WK1616004Supported by the National Natural Science Fundation of China(No.21472047, No.21772041, No.21702062), the Shanghai Oriental Scholar Distinguished Professor Project(No.GZ2016006), the Central University Basic Research Fellowship(No.WK1616004, No.222201717003, No.222201714013)the National Natural Science Fundation of China 21702062the National Natural Science Fundation of China 21772041the Central University Basic Research Fellowship 222201717003

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It is of great importance to selectively detect and effectively monitor zinc ion because of its wide distribution in human cells and vital roles in human metabolism. Fluorescent probes have been extensively applied in zinc sensing because of the advantages of simple-design, easy-operation, high sensitivity and cell imaging capability. Fluorescent zinc probes are generally constructed based on the mechanisms of photo-induced electron transfer, intra-molecular charge transfer, fluorescence resonance energy transfer, aggregation-induced emission and chelation-enhanced fluorescence. Among these mechanisms, zinc probes constructed on chelation-enhanced fluorescence have the advantages of easy design and synthesis because its fluorophore can simultaneously act as the receptor. In this review, fluorescent zinc probes based on the aforementioned mechanisms, especially, chelation-enhanced fluorescence, reported in recent years are briefly summarized.
- zinc ion,
- fluorescent probes,
- sensing mechanism,
- chelation-enhanced fluorescence,
- cell imaging
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沈阳化工大学材料科学与工程学院沈阳 110142