Citation: WANG Bing, HUANG Xiaobin, ZHAO Shan, ZHANG Jianbin, LYU Yan, LYU Guojun, MA Xiaojun. Improve the Properties of Resveratrol Solid Dispersions by Combined Polymers[J]. Chinese Journal of Applied Chemistry, ;2016, 33(12): 1383-1388. doi: 10.11944/j.issn.1000-0518.2016.12.160363 shu

Improve the Properties of Resveratrol Solid Dispersions by Combined Polymers

WANG Bing ^a,b ,
HUANG Xiaobin ^a ,
ZHAO Shan ^a,b ,
ZHANG Jianbin ^a,b ,
LYU Yan ^a,b ,
LYU Guojun ^a,, ,
MA Xiaojun ^a,,

1.
a Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China;
2.
b University of the Chinese Academy of Sciences, Beijing 100864, China

Corresponding author: LYU Guojun, MA Xiaojun,
Received Date: 9 September 2016
Available Online: 8 October 2016
Fund Project:

Resveratrol(Res) binary and ternary solid dispersions solid dispersions with poly(vinylpyrrolidone) (PVP) and hydroxypropylmethylcellulose(HPMC) were prepared by the solvent evaporation. Solid dispersions were characterized by Fourier transform infrared spectroscopy(FTIR), X-ray powder diffraction(XRD) and modulated differential scanning calorimetry(MDSC), and the release profiles were also invested. FTIR results reveal hydrogen bonding formed between Res and polymers. The release profiles of both Res solid dispersions are enhanced. However, XRD and MDSC results show that the miscibility of ternary solid dispersions is better than that of its binary solid dispersions. Under accelerated testing condition(40℃, 75%RH(relative humity)) for 3 months, XRD, MDSC and the release profiles indicate that Res ternary solid dispersions are more stable than that of its binary solid dispersions. The release profiles and stability of Res ternary solid dispersions are improved with the addition of HPMC.
- resveratrol,
- amorphous solid dispersion,
- hydrogen bonding,
- dissolution,
- stability
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