Citation: YANG Hongmei, XU Niusheng, YAO Wenbin, SHI Lei, LI Jinying, LIU Shuying. Research Progress on Interaction Between Small Ligands and Triplex DNA[J]. Chinese Journal of Applied Chemistry, ;2016, 33(12): 1355-1365. doi: 10.11944/j.issn.1000-0518.2016.12.160147 shu

Research Progress on Interaction Between Small Ligands and Triplex DNA

YANG Hongmei ^a,b ,
XU Niusheng ^b ,
YAO Wenbin ^a ,
SHI Lei ^c ,
LI Jinying ^c ,
LIU Shuying ^a,,

1.
a Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China;
2.
b Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3.
c CNEC High Temperature Reactor Holdings Co. Ltd., Beijing 100037, China

Corresponding author: LIU Shuying,
Received Date: 11 April 2016
Available Online: 10 May 2016
Fund Project:

Triplex DNA can interfere with gene transcription and expression modulation. It is one kind of important biological macromolecules. The interaction between small molecules and DNA targets plays an important role in the function of drug mediated physiological processes. In the past decades, numerous attempts have been made to screen triplex DNA binders. However, not too many effective methods for screening triplex DNA binders were reported. Basic principles, the screening methods of research and application for the interaction between small ligands and triplex DNA were summarized, including mainly the principle and application of several methods, such as competition dialysis, gold nanoparticle based approach, thermal denaturation method, centrifugal ultrafiltration method, electrospray ionization mass spectroscopy(MS) method, and liquid chromatography-mass spectroscopy(LC-MS) combined method. This review has a general instruction to the research of the interaction between small ligands and triplex DNA.
- ligands,
- triplex DNA,
- stability,
- screening method,
- application
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沈阳化工大学材料科学与工程学院沈阳 110142