Citation: LI Zhuheng, MA Lina, LIU Dianjun, WANG Zhenxin. Cytotoxicity of Gold Nanoparticles[J]. Chinese Journal of Applied Chemistry, ;2016, 33(9): 1009-1016. doi: 10.11944/j.issn.1000-0518.2016.09.160075 shu

Cytotoxicity of Gold Nanoparticles

LI Zhuheng ^a,b ,
MA Lina ^b ,
LIU Dianjun ^b ,
WANG Zhenxin ^b,,

1.
a Jilin Provincial Institute of Education, Changchun 130022, China;
2.
b State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: WANG Zhenxin,
Received Date: 29 February 2016
Available Online: 20 April 2016
Fund Project:

Gold nanoparticles(AuNPs) are one of ideal nanomaterials for constructing diagnostic and therapeutic nanosystems. Therefore, it is important to understand interactions of AuNPs and cells. In this review, we present a detailed analysis of data on the cytotoxicity of most popular AuNPs including gold nanoclusters(AuNCs), spherical AuNPs(AuNPss), gold nanoshells(AuNSs) and gold nanorods(AuNRs). We discuss the effects of the cell models, physicochemical properties(size, shape, chemical functionality, and surface charge) of AuNPs on the cytotoxicity of AuNPs. Some general conclusions, current challenges and future prospects/solutions on the issue have been provided.
- gold nanoparticles,
- mammalian cells,
- cytotoxicity,
- biological effect
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