Citation: DENG Youlin, TANG Shi, ZHANG Qian, WANG Qiong, PENG Menglu, YU Limin. Visible-light-induced Cascade Addition Cyclization of Alkenes Toward Perfluoroalkylated Isoquinolinediones[J]. Chinese Journal of Applied Chemistry, ;2016, 33(6): 685-692. doi: 10.11944/j.issn.1000-0518.2016.06.150317 shu

Visible-light-induced Cascade Addition Cyclization of Alkenes Toward Perfluoroalkylated Isoquinolinediones

1.
College of Chemistry and Chemical Engineering, Jishou University, Jishou, Hu'nan 416000, China

Corresponding author: TANG Shi,
Received Date: 31 August 2015
Available Online: 25 November 2015
Fund Project:

A visible-light-induced radical cascade addition cyclization reaction of activated alkenes with perfluoroalkyl iodide toward perfluorinated isoquinolinediones was developed. By visible-light photoredox catalysis, various N-alkyl-N-methacryloyl benamides underwent radical cyclization smoothly and afforded a series of synthetically important perfluorinated isoquinolinediones in 54%~80% yields. This work provides a highly efficient, mild condition, "green" means to pharmaceutically important perfluorinated isoquinolinediones.
- visible-light-induced,
- C-H cyclization,
- perfluoroalkyl iodides,
- perfluorinated isoquinolinedione
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沈阳化工大学材料科学与工程学院沈阳 110142