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Citation: DENG Xinwang, HU Huiyuan, LUO Zhongkuan, WU Maosheng, ZHOU Li. Preparation and Properties of Heparin Sodium/Polyvinyl Alcohol Composite Hydrogel[J]. Chinese Journal of Applied Chemistry, ;2015, 32(12): 1358-1363. doi: 10.11944/j.issn.1000-0518.2015.12.150228 shu

Preparation and Properties of Heparin Sodium/Polyvinyl Alcohol Composite Hydrogel

1.
College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China

Corresponding author: HU Huiyuan,
Received Date: 3 July 2015
Available Online: 14 August 2015
Fund Project: 深圳市科学与技术基金资助项目(JCYJ20140509172609151,JCYJ2013032910261471,JCYJ20120613112258764) (JCYJ20140509172609151,JCYJ2013032910261471,JCYJ20120613112258764)

Heparin sodium/polyvinyl alcohol(HS/PVA) composite hydrogel was prepared successfully by the cyclic freezing-thawing method. Effects of mass fraction of heparin sodium on visible light transmittance,moisture content,hydrophilcity,mechanical property and percentage of heparin sodium release of composite hydrogel were studied. The results show that the introduction of heparin sodium into the structure of PVA can enhance the moisture content and hydrophilic of HS/PVA composite hydrogel,simultaneously,reduce visible light transmittance and mechanical properties of HS/PVA composite hydrogel. The release of heparin sodium from HS/PVA composite hydrogel resists the cell adhesion. Therefore,the HS/PVA composite hydrogel has a potential application in the fields of optical central materials of artificial cornea.
- heparin sodium,
- polyvinyl alcohol,
- composite hydrogel,
- artificial cornea,
- cell adhesion
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