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Citation: JIN Jianzhong, WEN Ming, SHEN Chao, XU Tianhua. Catalytic Hantzsch Reaction in Aqueous Phase[J]. Chinese Journal of Applied Chemistry, ;2015, 32(12): 1392-1397. doi: 10.11944/j.issn.1000-0518.2015.12.150178 shu

Catalytic Hantzsch Reaction in Aqueous Phase

JIN Jianzhong ^a,, ,
WEN Ming ^a,b ,
SHEN Chao ^a ,
XU Tianhua ^c

1.
a College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China;
2.
b College of Petroleum Chemical Industry, Changzhou University, Changzhou, Jiangsu 213164, China;
3.
c Zhejiang Esigma Animal Health Co., Ltd., Haining, Zhejiang 314400, China

Corresponding author: JIN Jianzhong,
Received Date: 21 May 2015
Available Online: 10 August 2015
Fund Project: 国家自然科学基金青年科学基金资助项目(21376058) (21376058)

Aqueous catalytic Hantzsch reaction has been studied with aryl aldehyde,ethyl acetoacetate and ammonium salt. The influences of catalysts,substrate ratio and reaction temperature have been evaluated to optimize the reaction conditions. The optimum reaction conditions were:5 mmol benzaldehyde,0.5 mmol DL-proline,2.5 mmol(NH₄)₂CO₃,10 mL water,reaction time 5 h and reaction temperature 70℃. The productivity was 90.1% under the determined optimum reaction conditions. Recycle of catalysts did not show compromise of catalytic activity. The reaction displayed wide scope of aryl aldehyde. All products were confirmed with IR and NMR spectra. Reaction has the advantages of environment friendly,mild conditions,simple operation and high yield. Results show that aqueous catalytic Hantzsch reaction has wide applicability.
- aqueous phase,
- Hantzsch reaction,
- catalytic cycle
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