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Citation: WAGN Susu, ZHANG Yue, LI Hui, XU Miaomiao. Preparation,Characterization and Recognition Behavior of Quercetin-Rutin Bi-template Molecularly Imprinted Polymers[J]. Chinese Journal of Applied Chemistry, ;2015, 32(11): 1290-1298. doi: 10.11944/j.issn.1000-0518.2015.11.150145 shu

Preparation,Characterization and Recognition Behavior of Quercetin-Rutin Bi-template Molecularly Imprinted Polymers

WAGN Susu ^a ,
ZHANG Yue ^a ,
LI Hui ^a,b,, ,
XU Miaomiao ^a

1.
a College of Chemistry and Chemical Engineering, Jishou University, Jishou, Hu'nan 416000, China;
2.
b Key Laboratory of Plant Resource Conservation and Utilization, Jishou University, Jishou, Hu'nan 416000, China

Corresponding author: LI Hui,
Received Date: 23 April 2015
Available Online: 23 July 2015
Fund Project: 国家自然科学基金面上项目(21077042) (21077042)吉首大学研究生专项(编号:37) (编号:37)

A bi-templates molecular imprinted polymers(MIPs) was prepared by using quercetin(QT) and rutin(RT) as co-templates. The preparation conditions were optimized. The effects of the molar ratio of two templates and the volume dosage of functional monomer and crosslinker on the adsorption property of MIPs were also studied. Structural characterization of the MIPs was performed by FTIR and SEM. The adsorption dynamics,adsorption isotherm,surface sites distribution and binding selectivity of the MIPs were explored. In addition,the applicability for the MIPs to separate target compound by MIPs solid phase extraction was studied. When the molar ratio of quercetin to rutin is 3:2 and the molar ratio of total templates to functional monomer to cross-linker is 1:8:10,the MIPs obtained possess the highest adsorption capacity toward two templates(47.86 mg/g for quercetin and 60.97 mg/g for rutin). The equilibrium of static adsorption is reached within 3.5 h implying a rapid adsorption dynamics. Scatchard analysis shows that there are four types of binding sites in the polymer matrix,i.e.,two types of high affinity binding sites toward two templates and two types of non-selective recognition sites. The relative distribution coefficient(k=K_d(RT)/Kd(QT),K_d=q_e/ρ_e,K_d-distribution coefficient,q_e-equilibrium adsorption amount,ρ_e-equilibrium mass concentration) much higher than 1.0 reveals a high selectivity for the MIPs toward rutin. The highest relative distribution coefficient(6.669) and separation factor(α=q_e(RT)/q_e(QT))(25.02) are obtained when the concentration of rutin and quercetin in the model mixture is 0.07 and 0.03 mmol/L,respectively. When using acetonitrile,methanol and methanol-acetic acid mixture as effluents in sequence in the MIPs solid phase extraction of crude extract of sophora flower bud,quercetin and rution can be separately extracted with 96.70% and 94.67% recoveries,respectively.
- molecularly imprinted polymers,
- quercetin,
- rutin,
- mixed-templates imprinting,
- molecular recognition
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