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Citation: ZHAO Xia, CHEN Limin, HU Jun, ZHANG Xiaolei, LUCKANAGUL Jittima Amie, LIN Yuan, WANG Qian. In vivo Immune Response Using Tobacco Mosaic Virus as Hapten Carrier[J]. Chinese Journal of Applied Chemistry, ;2015, 32(10): 1107-1113. doi: 10.11944/j.issn.1000-0518.2015.10.150116 shu

In vivo Immune Response Using Tobacco Mosaic Virus as Hapten Carrier

1.
a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
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b University of South Carolina, South Carolina 29208, USA

Corresponding author: LIN Yuan, WANG Qian,
Received Date: 25 March 2015
Available Online: 7 May 2015
Fund Project: 国家自然科学基金(21429401,21374119)资助项目 (21429401,21374119)

Using a lysine mutant of tobacco mosaic virus (TMV-EPMK) as the hapten carrier,artificial TMVEPMK/E3 antigens were fabricated by conjugating a small molecular estriol (E3) onto TMV-EPMK through "click" chemistry,and their immune response was evaluated in BALB/c mice.The results demonstrated that TMV-EPMK/E3 antigen containing the hydrophilic linker could enhance the E3 specific immune response with the higher Ig G antibody level (titer 21800) by displaying E3 on TMV surface with distinctive topology.This study investigated that immune response was affected by linker property using TMV as the hapten carrier.A hydrophilic linker could elicit a stronger immune response.
- TMV-EPMK,
- click chemistry,
- hapten,
- artificial antigen,
- immune response
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