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Citation: LIN Sen, WU Yadi, DENG Ruihong, CAO Qianyong. Synthesis,Structure and Antitumour Activity of Cyclohexyl ((trimethylsilyl) methyl) stannanediyl Bisarylcarboxylates[J]. Chinese Journal of Applied Chemistry, ;2015, 32(10): 1114-1119. doi: 10.11944/j.issn.1000-0518.2015.10.150059 shu

Synthesis,Structure and Antitumour Activity of Cyclohexyl ((trimethylsilyl) methyl) stannanediyl Bisarylcarboxylates

1.
Department of Chemistry, Nanchang University, Nanchang 330031, China

Corresponding author: LIN Sen,
Received Date: 6 February 2015
Available Online: 19 May 2015
Fund Project: 国家自然科学基金资助项目(21162017) (21162017)

Eight cyclohexyl ((trimethylsilyl) methyl) stannanediyl bisarylcarboxylates were synthesized by the reaction of cyclohexyl (trimethylsilylmethyl) tin dichloride with arylcarboxylic acids.These compounds were characterized by IR,¹H NMR and ¹³C NMR spectra and elemental analysis.The preliminary bioassay tests of these compounds show good antitumour activities in vitro against tumour cells A549 and the inhibition rates are over 75%.
- diorganotin,
- synthesis,
- structure,
- antitumour activity
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