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Citation: DUAN Zhifang, SHAO Ling. Solid Phase Synthesis and Biological Activity of Flavone Derivatives Containing Salicylidene Schiff Bases[J]. Chinese Journal of Applied Chemistry, ;2015, 32(9): 1005-1013. doi: 10.11944/j.issn.1000-0518.2015.09.150032 shu

Solid Phase Synthesis and Biological Activity of Flavone Derivatives Containing Salicylidene Schiff Bases

DUAN Zhifang ^a,b,, ,
SHAO Ling ^a

1.
a College of Life Science, Zhaoqing University, Zhaoqing, Guangdong 526061, China;
2.
b Biopharmaceutical Research and Development Center, Zhaoqing University, Zhaoqing, Guangdong 526061, China

Corresponding author: DUAN Zhifang,
Received Date: 26 January 2015
Available Online: 3 April 2015
Fund Project: 肇庆市创新科技基金资助项目(2012G25) (2012G25)

The 7-o-formylphenoxy ethoxy flavone was obtained from salicylaldehyde and 7-bromoethoxy flavones by solid phase synthetic method.Then fourteen flavone derivatives containing salicylidene Schiff bases were synthesized by the solid phase condensation reaction of 7-salicylidene ethoxy flavone with substituted N⁴-substituted semicarbazides,N⁴-substituted thiosemicarbazides and N-phenylglycine hydrazides.These new compounds were characterized by IR,¹H NMR,ESI-MS and EA or HR-MS.Their scavenging effects on the superoxide radical (O₂^-·),hydroxyl radical (·OH) and DPPH·radical and their total reduction activities as well as the antimicrobial activities in vitro were evaluated.At 0.5 g/L concentration,most of the title compounds exhibit antioxidation effects and relatively antibacterial activity.Among them,the antibacterial activity of compound 3b is comparable to that of the control drug chloramphenicol.
- salicylidene schiff bases,
- flavone,
- solid phase synthesis,
- antioxidation,
- antibacterial
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