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Citation: ZHANG Baohua, SHI Lanxiang, LIU Shengbao. Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH₂)₂]₃Cl₂ Ionic Liquid[J]. Chinese Journal of Applied Chemistry, ;2015, 32(7): 743-747. doi: 10.11944/j.issn.1000-0518.2015.07.140383 shu

Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH₂)₂]₃Cl₂ Ionic Liquid

1.
a College of Chemical Engineering, Shijiazhuang University, Shijiazhaung 050035, China;
2.
b Baoding Traditional Chinese Medicine Pharmaco., Itd, Baoding, Hebei 071200, China

Corresponding author: SHI Lanxiang,
Received Date: 6 November 2014
Available Online: 19 January 2015
Fund Project: 河北省科技支撑项目(13964002D) (13964002D)石家庄学院平台基金项目(XJPT007)资助 (XJPT007)

A method for direct asymmetric chlorination of aldehydes and 2,3,4,5,6,6-hexachloro-2,4-cyclohexadien-1-one catalyzed by Pro-Trp in the presence of N-methylmorpholine (NMM) and ionic liquid Zn[CO(NH₂)₂]₃Cl₂has been developed.This method produces the corresponding optically active chlorinated products with high yields (up to 95%) and good enantioselectivities (up to 92% ee).The approach has advantages in simple isolation and reusablility of catalyst and ionic liquids.
- hexachloro-cyclohexadien-one,
- ionic liquid,
- dipeptide,
- chlorination,
- aldehyde
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Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH₂)₂]₃Cl₂ Ionic Liquid