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Citation: ZHANG Tian-Qi, HAN Xue-Li, HE Yang-Yang, HE Xiao-Jing, WANG Jian-Qiu, YUAN Qing-Hai, LIU Jian-Hua. Facile Synthesis of PEGylated Tungsten-based Nanoprobes for Gastric Computed Tomography Imaging[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(10): 1539-1544. doi: 10.11895/j.issn.0253-3820.181483 shu

Facile Synthesis of PEGylated Tungsten-based Nanoprobes for Gastric Computed Tomography Imaging

1.
Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, China;
2.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China;
3.
Department of Pathology, the Second Hospital of Jilin University, Changchun 130041, China;
4.
Department of Radiology, the Second Hospital of Chongqing Medical University, Chongqing 400010, China

Received Date: 24 July 2018
Revised Date: 16 August 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 81571737), the Program of Science and Technology Development Plan of Jilin Province of China (No. 2018010119JC), the Youth Training Foundation by the Health and Family Planning Commission of Jilin Province (No. 2017Q012), the Health Special Project of Jilin Province Department of Finance (No. 20180029) and the Medical Researching Program by the Health and Family Planning Commission of Chongqing City (No. 2016MSXM024).

Polyethyleneglycol (PEG)-modified (PEGylated) nanoprobes have attracted a great deal of interest in the area of molecular imaging area along with the rapid development of modern medicine. These nanoprobes play an important role especially in the diagnosis and prognosis of gastric diseases. The transition metal oxides as gastric contrast agents based on PEGylated WO_3-x nanoprobes (PEG-WO_3-x) were designed and synthesized. The nanoprobes ewere synthesized via a high-temperature solvent thermal method, and then modified with PEG. These PEGylated nanoprobes exhibited excellent aqueous stability. Besides evaluating the characteristics of PEG-WO_3-x, in vivo, toxicological studies were carried out with histopathology. Otherwise, as a contrast agent, MDCT imaging was illustrated via both in vitro and in vivo assessment. The experimental results indicated that the prepared PEG-WO_3-x showed great potential for further MDCT imaging in detection of gastric diseases.
- Transition metal oxides,
- WO_3-x,
- Nanoprobes,
- PEGylated,
- Contrast agent
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1.
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