Citation: ZHANG Tian-Qi, HAN Xue-Li, HE Yang-Yang, HE Xiao-Jing, WANG Jian-Qiu, YUAN Qing-Hai, LIU Jian-Hua. Facile Synthesis of PEGylated Tungsten-based Nanoprobes for Gastric Computed Tomography Imaging[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(10): 1539-1544. doi: 10.11895/j.issn.0253-3820.181483
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Polyethyleneglycol (PEG)-modified (PEGylated) nanoprobes have attracted a great deal of interest in the area of molecular imaging area along with the rapid development of modern medicine. These nanoprobes play an important role especially in the diagnosis and prognosis of gastric diseases. The transition metal oxides as gastric contrast agents based on PEGylated WO3-x nanoprobes (PEG-WO3-x) were designed and synthesized. The nanoprobes ewere synthesized via a high-temperature solvent thermal method, and then modified with PEG. These PEGylated nanoprobes exhibited excellent aqueous stability. Besides evaluating the characteristics of PEG-WO3-x, in vivo, toxicological studies were carried out with histopathology. Otherwise, as a contrast agent, MDCT imaging was illustrated via both in vitro and in vivo assessment. The experimental results indicated that the prepared PEG-WO3-x showed great potential for further MDCT imaging in detection of gastric diseases.
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Keywords:
- Transition metal oxides,
- WO3-x,
- Nanoprobes,
- PEGylated,
- Contrast agent
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