Citation: CUI Lin, LI Meng, ZOU Xiao-Ran, ZHANG Chun-Yang. Advances in Development of Ratiometric Electrochemical Sensors and Their Biochemical Applications[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(11): 1685-1694. doi: 10.11895/j.issn.0253-3820.181462 shu

Advances in Development of Ratiometric Electrochemical Sensors and Their Biochemical Applications

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Received Date: 16 July 2018
Revised Date: 28 August 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21325523, 21605096) and the Award for Team Leader Program of Taishan Scholars of Shandong Province, China.

The electrochemical sensors have been widely applied in the fields of disease diagnosis, environmental monitoring and food safety due to their advantages such as simplicity, rapidity, high sensitivity, low-cost, easy miniaturization and on-line analysis. However, the conventional electrochemical sensors suffer from low stability and poor reproducibility. The ratiometric electrochemical sensors may overcome these issues by adopting a dual-signal mode, i.e., "one-to-two" signal output resulting from two label-redox molecules, which can efficiently overcome the potential interference from the inherent background electrochemical signals and improve the sensitivity and selectivity. In this review, we summarize the principles of ratiometric electrochemical sensors and their applications in sensitive detection of proteins, DNA, small biological molecules and metal ions. Moreover, we give new insight into the future direction and challenges in the development of ratiometric electrochemical sensors.
- Ratiometric electrochemistry,
- Ultrasensitive detection,
- Biochemical analysis,
- Review
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