Citation: DU Zai-Hui, LI Xiang-Yang, TIAN Jing-Jing, ZHANG Yang-Zi, TIAN Hong-Tao, XU Wen-Tao. Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(7): 995-1004. doi: 10.11895/j.issn.0253-3820.171444 shu

Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor

1.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100000, China;
2.
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100000, China;
3.
College of Food Science and Technology, Agricultural University of Hebei, Baoding 071000, China;
4.
Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China

Received Date: 22 November 2017
Revised Date: 24 March 2018

Fund Project: This work was supported by the Beijing New-Star Plan of Science and Technology (No. xxjc201721) and the National Natural Science Foundation of China (No.31671922).

Functional nucleic acids are natural or artificialnucleic acid sequences with specific functions and special structures. Special metal ions are essential trace elements for human health, but excessive metal ions will be harmful to human health. The functional nucleic acids are widely used in the detection of metal ions because of their advantages such as easy modification, low price, high stability and strong specificity. This review describes the function of functional nucleic acid and metal ions, mainly including cutting type, link type, metal ion-mediated base pairing, click chemical type, conformation change type, and other types. Then, biosensor of functional nucleic acid combined with different signal output is introduced. Finally, the research significance and problems of functional nucleic acid in metal ion detection are discussed, and the future development direction and application prospect of functional nucleic acid biosensor are prospected.
- Functional nucleic acid,
- Metal ions,
- Mode of action,
- Biosensor,
- Review
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