Citation: WANG Yi, ZHANG Ping, WU Sheng-Xiu, LIU Xiu-Peng, LUO Rui, QIN Xiong-Wei, CHEN Wu-Gong, CHEN Li, ZHAO Tong. Application of Silylation in Mass Spectrometry Analysis of Organic Halides[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(10): 1560-1569. doi: 10.11895/j.issn.0253-3820.171233 shu

Application of Silylation in Mass Spectrometry Analysis of Organic Halides

Xi'an Manareco New Materials Co., Ltd, Xi'an 710077, China

Received Date: 6 November 2017
Revised Date: 31 August 2018

A gas chromatography-mass spectrometry (GC-MS) method was used for investigation of the fragmentation behavior of a series of trimethylsilyl (TMS) derivatives of aliphatic halides and aromatic halides under the environment of electron impact ion source (EI) in order to acquire it's fragmentation regularity, which, in return, provided guidance for the structure of organic halogenated compounds. The results of mass spectral indicated that the TMS derivatives of organic halides produced characteristic skeleton rearrangement product ions with elemental composition conforming to[(CH₃)₂XSi]⁺(X=F, Cl, Br, I) during the fragmentation reaction, namely m/z 77, m/z 93, m/z 137 and m/z 185. In addition, the change in the position of the halogen atom substitution also had significant effect on the intensity and type of the rearranged product ion peak. Through the study of this type of rearranged product ions, the positional isomers of the halogenated compounds could be identified quickly and efficiently, and the elemental composition of the organic molecules could be reversely analyzed. This analysis method not only provided a new idea for the analysis of the structure of organic halogenated compounds, but also expanded the application of silane derivatization reagents in the field of organic mass spectrometry.
- Gas chromatography-mass spectrometry,
- Silylation,
- Skeleton rearrangement,
- Position isomer,
- Organic halides
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沈阳化工大学材料科学与工程学院沈阳 110142