Citation: XU Xiao-Ying, LIU Zhu, ZHU Bing-Qi, LIANG Jing-Jing, CHEN Wan-Qin, LUO Jin-Wen. Simultaneous Determination of 10 Kinds of Algal Toxins in Water Samples by Online Solid Phase Extration Coupled with Ultra High Performance Liquid Chromatography-Quadrupole Linear Ion Trap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(11): 1703-1710. doi: 10.11895/j.issn.0253-3820.170339 shu

Simultaneous Determination of 10 Kinds of Algal Toxins in Water Samples by Online Solid Phase Extration Coupled with Ultra High Performance Liquid Chromatography-Quadrupole Linear Ion Trap Mass Spectrometry

Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China

Received Date: 27 May 2017
Revised Date: 29 August 2017

An online solid phase extraction (online-SPE) combined with ultra high performance liquid chromatography-quadrupole linear ion trap mass spectrometry (UHPLC-MS/MS-Qtrap) was established for the simultaneous identification and determination of 10 kinds of algal toxins in water samples. Multiple injections of water samples were controlled by a preset program, and the target analytes were enriched by trap column. The six-way valve was switched subsequently, and the algal toxins in the trap column were back-flushed to the analytical column for separation and analysis. The results showed that the online SPE significantly simplified pretreatment process, and the linear ion trap tandem mass spectrometry improved the sensitivity of the determination. Moreover, the establishment of enhanced product ion (EPI) scan library provided evidence for the confirmation of algal toxins. The 10 kinds of algal toxins showed a good linear relationship with correlation coefficient R²>0.99. The limits of detection (LOD) were 0.0015-0.0050 μg/L. The mean recoveries at three spiked levels of 0.02, 0.1, 1.0 μg/L were from 83.7% to 98.5%. The method was suitable for the rapid confirmation and quantitative determination of various algal toxins in water.
- Algal toxins,
- Online-solid phase extraction,
- Ultra performance liquid chromatography-quadrupole linear ion trap mass spectrometry,
- Water
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沈阳化工大学材料科学与工程学院沈阳 110142