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Citation: KONG Xiang-Yi, DU Jian-Shi, MA Ming, XU Jin-Ling, LI Shui-Ming, WANG Yong, ZHAO Qing. Study of Alzheimer's Disease Biomarkers Based on Serum Peptidomics[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(7): 937-943. doi: 10.11895/j.issn.0253-3820.170248 shu

Study of Alzheimer's Disease Biomarkers Based on Serum Peptidomics

KONG Xiang-Yi ^1, ,
DU Jian-Shi ² ,
MA Ming ³ ,
XU Jin-Ling ⁴ ,
LI Shui-Ming ⁴ ,
WANG Yong ⁴ ,
ZHAO Qing ³

1.
Norman Bethune Health Science Center of Jilin University, Changchun 130021, China;
2.
Department of Vascular surgery, China-Japan Union Hospital, Changchun 130033, China;
3.
Department of Neurology, China-Japan Union Hospital, Changchun 130033, China;
4.
College of Life Science and Oceanography, Shenzhen Key Laboratory of Marine Bioresources and Ecology, Shenzhen University, Shenzhen 518060, China

Received Date: 18 April 2017
Revised Date: 17 May 2017

Early diagnosis and intervention is an important way to delay the progress of Alzheimer's disease (AD). Compared with cerebrospinal fluid, blood sampling is not invasive and easy to be obtained in clinic practice. In this study, the serum samples of 9 controls, 10 AD and 12 mild cognitive dysfunction (MCI) patients were analyzed and compared through one by one analysis to screen potential markers for AD diagnosis. The experimental results showed that VGFYESDVMGR of α-2-macroglobulin peptide was closely related to the late stage of AD disease, and the large amount degradation of apolipoprotein C-Ⅲ, histone H1.2 and histone H1.4 was significantly related to early stages of AD progression. The characteristics of serum peptidome were different for the early and late AD, and these four proteins may be used as potential biomarkers of AD disease. In addition, the obvious ladder sequence characteristic was observed for apolipoprotein C-Ⅲ and histone H1, which could partly explain why the peptides distribution in different samples was somewhat contingent. On the contrary, the distribution at protein level was more stable. Finally, it was confirmed that the peptides of proteins such as fibrinogen α-chain, thymosin β-4 and patchy proteins were the dominant peptides in all serum samples. Overall, this study showed that the method of using serum peptidomics to diagnose AD was possible. The results may provide evidence and references for the large-scale clinical validation of AD.
- Peptidomics,
- Biomarker,
- Serum,
- Alzheimer's disease,
- Mild cognitive impairment
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
1. [1]
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