Citation: ZHAO Yan, GUO Lin-Jie, DAI Jiang-Bing, LI Qian, LI Di, WANG Li-Hua. Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(7): 1078-1087. doi: 10.11895/j.issn.0253-3820.170157 shu

Application Progress of DNA Nanostructures in Drug Delivery and Smart Drug Carriers

ZHAO Yan ^1,2, ,
GUO Lin-Jie ¹ ,
DAI Jiang-Bing ^1,2 ,
LI Qian ¹ ,
LI Di ¹ ,
WANG Li-Hua ¹

1.
Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Chinese Academy of Sciences, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 6 March 2017
Revised Date: 2 May 2017

Fund Project: This work was supported by National Natural Science Foundation of China (Nos. 11575278, No.21675167)

Nanocarrier systems have been widely used for improving solubility, stability and therapeutic activity of drugs due to their high drug-loading efficiency, good target specificity and long circulation time. To achieve precisely controlled loading and tumor-selective release of drugs, extensive research efforts have been focused on developing nanocarriers with low toxicity, excellent biocomapatibility and biodegradability. As a type of nano-biomaterials with various functions and applications, self-assembled DNA nanostructures explored new ways to develop drug carriers in smart drug delivery based on their well-defined structures, good biocompatibility and stability, high cell membrane permeability and controlled drug releasing property. In this review, we summarized the developing course and the recent advances of DNA nanostructures for drug delivery, including the application of both static and dynamic DNA nanostructures. The application of dynamic DNA nanostructures for controlled drug release showed great potential in smart drug delivery.
- DNA nanostructures,
- Drug delivery carriers,
- Smart drug delivery,
- Review
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