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Citation: CHEN Zhao-Hui, LI Yuan-Yuan, HAN Juan, WANG Yun, REN Yan-Peng, CHEN Tong, TANG Xu, NI Liang. Synthesis and Biological Application of A Water-Soluble Fluorescent Probe Based on Coumarin Derivatives for Detection of Ferric Ion[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(1): 20-26. doi: 10.11895/j.issn.0253-3820.170114 shu

Synthesis and Biological Application of A Water-Soluble Fluorescent Probe Based on Coumarin Derivatives for Detection of Ferric Ion

CHEN Zhao-Hui ^1, ,
LI Yuan-Yuan ² ,
HAN Juan ³ ,
WANG Yun ¹ ,
REN Yan-Peng ¹ ,
CHEN Tong ⁴ ,
TANG Xu ¹ ,
NI Liang ¹

1.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China;2 Jingjiang college, Jiangsu University, Zhenjiang 212013, China;3 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China;4 Zhenjiang Entry-exit Inspection and Quarantine Bureau, Zhenjiang 212000, China

Received Date: 26 February 2017
Revised Date: 23 November 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21576124).

A water-soluble fluorescent probe (7-diethyl amino-3-formaldehyde coumarin) for Fe³⁺ detection was designed and synthesized, and its structure was confirmed by ¹HNMR, ¹³CNMR and MS spectra. This probe showed high emission intensity at 471 nm. With the continuous addition of Fe³⁺, the emission intensities at 471 nm decreased gradually, and showed an excellent linearity with Fe³⁺ in the range of 0.02-60 μmol/L, and the regression equation was I=322.56-4.86C_Fe³⁺. This probe was able to detect Fe³⁺ qualitatively and quantitatively with the detection limit as low as 22 nmol/L. Besides, this probe showed high sensitivity to Fe³⁺ over other metal ions. The detection process was reversible, which could be recycled for the Fe³⁺ detection. In terms of good optical properties and the strong fluorescence in physiological pH, the probe was successfully applied in imaging Fe³⁺ of living Ramos cells.
- Fluorescent probe,
- Ferric ion,
- Water solubility,
- Cell imaging
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