Citation: FU Yu, LI Xiao-Dong, LI Zhu-Heng, CHEN Hong-Da, WANG Zhen-Xin, ZHANG Hui-Mao, WANG Hai-Feng. Effect of Surface Charge on Biobehavior of PEGylated Gold Nanoparticles[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(7): 1038-1044. doi: 10.11895/j.issn.0253-3820.170085 shu

Effect of Surface Charge on Biobehavior of PEGylated Gold Nanoparticles

1.
Department of Neurosurgery, the First Hospital of Jilin University, Changchun 130021, China;
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Department of Radiology, the First Hospital of Jilin University, Changchun 130021, China;
3.
Jilin Provincial Institute of Education, Changchun 130022, China;
4.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China

Received Date: 24 February 2017
Revised Date: 22 March 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (No.81571737)

Three kinds of PEGylated gold nanoparticles (PEG-Au NPs) with different surface charges are prepared by assembly of thiolated polyethylene glycol (HS-PEG) with different terminal groups including methoxy, amino or carboxyl on gold nanoparticle surface through sulfur-gold covalent bond, respectively. The experimental results of cell co-culturing and tail intravenous injection in mouse indicate that the biological behaviors of PEG-Au NPs are affected significantly by their surface charges. The cellular internalization amounts of PEG-Au NPs are following the order, positive charge > neutral charge > negative charge. The PEG-Au NPs are gradually transferred to liver and spleen from main organs through the circulation of blood after tail intravenous injection in mouse. The negatively charged PEG-Au NPs have the slowest hepatic clearance rate while the positively charged PEG-Au NPs can cause the strongest response of immune system in mice.
- PEGylated,
- Gold nanoparticles,
- Living cells,
- Biodistribution,
- Biocompatibility.
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沈阳化工大学材料科学与工程学院沈阳 110142