Citation: NAN Qiong, TANG Jing-Chun, HE Ruo-Zhu, HU Yu-Cheng, WU Tao. Determination of Furazolidone and Florfenicol in Soil by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(11): 1600-1605. doi: 10.11895/j.issn.0253-3820.160870 shu

Determination of Furazolidone and Florfenicol in Soil by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry

NAN Qiong ^1, ,
TANG Jing-Chun ^1,2,3 ,
HE Ruo-Zhu ¹ ,
HU Yu-Cheng ⁴ ,
WU Tao ⁴

1.
College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;
2.
Key Laboratory of Pollution Processes and Environmental Criteria, Ministry of Education, Tianjin 300071, China;
3.
Tianjin Engineering Center of Environmental Diagnosis and Contamination Remediation, Tianjin 300071, China;
4.
Tianjin Hydranlic Research Insitute, Tianjin 300061, China

Received Date: 28 November 2016
Revised Date: 4 September 2017

A detection method for furazolidone and florfenicol in soil with various environmental matrices was established using ultra performance liquid chromatography-tandem spectrometry (UPLC/MS/MS) technique. Extracting solution of a mixture of phosphate buffer (pH=3) and acetonitrile (3:7, V/V) was used in this experiment. The extracted water samples were enriched by SAX-HLB solid phase extraction column before the process of nitrogen blowing (high purity nitrogen). The enriched antibiotics were desalted with 8 mL of methanol. Waters BEH C₁₈ (2.1×100 mm) column was used for the sample separation. UPLC/MS/MS was carried out for qualitative and quantitative analysis under multi-reaction monitoring mode. The detection limit of the method was determined by 3 times of signal-to-noise ratio, and the limit of determination of the method was determined by 10 times of signal-to-noise ratio. The results showed that the detection limits of furazolidone and florfenicol were 1.19 and 0.41 μg/kg, respectively, and the limits of quantitation of furazolidone and florfenicol were 3.40 and 1.37 μg/kg, respectively. Besides, recovery experiment showed that, for the soil samples spiked with 50 μg/L furazolidone and florfenicol, the recoveries were 79% for florfenicol and 92% for furazolidone. Similarly, for the soil samples spiked with 200 μg/L furazolidone and florfenicol, the recoveries were 96% for furazolidone and 86% for florfenicol.
- Ultra performance liquid chromatography-tandem spectrometry,
- Furazolidone,
- Florfenicol,
- Solid phase extraction
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