Citation: XIAO Yi-Po, LU Hai-Yan, LÜ Shao-Jun, XIE Shao-Xian, WANG Zhao-Zheng, CHEN Huan-Wen. Rapid Analysis of Trace Salbutamol and Clenbuterol in Pork Samples by Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(11): 1633-1638. doi: 10.11895/j.issn.0253-3820.160535 shu

Rapid Analysis of Trace Salbutamol and Clenbuterol in Pork Samples by Mass Spectrometry

1.
East China Institute of Technology, Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, Nanchang 330013, China;
2.
Sports Science Institute of Jiangxi Province, Nanchang 330006, China

Received Date: 14 July 2016
Revised Date: 14 September 2016

Fund Project: This work was supported by the program for changjiang Scholars and Innovation Research Team in Universities (No. IRT13054), Jiangxi Province Science and Technology Landmark Project (No.KJLD13051), China Academy of Metrology Science and Technology (No. 40-AKYKF1601)

Salbutamol and Clenbuterol are often used as β-agonists and illegally added in pig feed, resulting in pork contaminated and even leading athletes excessive excitability. Therefore, it has great significance for establishing a new rapid detection method of salbutamol and clenbuterol in pork. In this study, internal extraction electrospray ionization-mass spectrometry (iEESI-MS) technology was used for directly qualitative and quantitative analysis of salbutamol and clenbuterol in pork tissues without sample pretreatment. The results showed that this method had a high sensitivity to salbutamol and clenbuterol analysis with detection limits of (LOD) 6.2 and 9.8 ng/kg, respectively, while the analysis time for detecting single sample and single index was less than 30 s. In a concentration range of 0.01-1000 μg/kg, the logarithm of signal intensity (Y) and the logarithm of concentration (X) have a good linear relationship. This method has many advantages such as rapid analysis, low sample consumption and high sensitivity, which is ideal for rapid detection of trace salbutamol and clenbuterol.
- Internal extraction electrospray ionization,
- Salbutamol,
- Clenbuterol,
- β-Agonists,
- Organizational analysis
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