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Citation: HAN Wan-Qing, WANG Bin, WU Chu-Sen, WU Hui-Qin, WU Yu-Luan, LUO Hai-Ying. Determination of 15 Kinds of Plants Originated Stimulants and Exogenous Medicines Using Solid Phase Extraction Combined with UPLC-MS/MS[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(10): 1584-1592. doi: 10.11895/j.issn.0253-3820.160265 shu

Determination of 15 Kinds of Plants Originated Stimulants and Exogenous Medicines Using Solid Phase Extraction Combined with UPLC-MS/MS

1.
Guangzhou Quality Supervision and Testing Institute, National Centre for Quality Supervision and Testing of Processed Food (Guangzhou), Guangzhou Key Laboratory of Detection Technology for Food Safety, Guangzhou Research Centre of Risk Dynamic Detection and Early Warning for Food Safety, Guangzhou 510000, China;
2.
China National Analytical Center (Guangzhou), Guangzhou 510000, China

Received Date: 6 April 2016
Revised Date: 19 June 2016

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An effective method was developed for the simultaneous determination of 15 kinds of plants originated stimulants and exogenous medicines in herbal tea using solid phase extraction (SPE) combined with ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After centrifugation in high speed, the samples were purified using HLB SPE column at pH 4.0 (adjusted by formic acid). A total of 15 targets were separated on a BEH C₁₈ column by gradient elution with acetonitrile-0.1% formic acid as mobile phase, ionized with positive and negative electrospray ionization (ESI+/-), detected under multiple reaction monitoring (MRM) mode, and quantified with external standard method. The method was validated by evaluating the linearity, recoveries, and precision. Favorable linearity was acquired in the concentration range of 1.0-200 μg/L, and the limits of detection (LODs) were ranged from 0.1 to 2.0 μg/L. At the spiked levels of 2.0-100 μg/L, the average recoveries presented 76.4%-107.0%, with the relative standard deviation (RSD, n=6) of 2.8% to 9.7% and intra-day precision of 2.7%-12.0%. The procedure was successfully applied to the determination of plants originated stimulants and external medicines in commercial herbal tea.
- Herbal tea,
- Stimulant,
- Medicine,
- Ultra-high performance liquid chromatography tandem mass spectrometry-,
- Solid phase extraction
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