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Citation: FAN Yan, WANG Yang, LIU Jun-Tao, LUO Jin-Ping, XU Hui-Ren, XU Sheng-Wei, CAI Xin-Xia. Development of Portable Device for Point-of-Care Testing of Tumor Marker[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(7): 1148-1154. doi: 10.11895/j.issn.0253-3820.160079 shu

Development of Portable Device for Point-of-Care Testing of Tumor Marker

FAN Yan ^1,2,3, ,
WANG Yang ^1,2 ,
LIU Jun-Tao ^1,2 ,
LUO Jin-Ping ^1,2 ,
XU Hui-Ren ^1,2 ,
XU Sheng-Wei ^1,2 ,
CAI Xin-Xia ^1,2

1.
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 10090, China;
3.
Intelligence and Information Engineering College of Tangshan University, Tangshan 063000, China

Received Date: 29 January 2016
Revised Date: 1 March 2016

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 61527815, 61471342, 31500800, 61501426)

Figures(6)

By combining electrochemical detection technique and electronic technique, a portable device which adopted differential pulse voltammetry (DPV) measurement was developed to meet the needs of high sensitivity and on-site rapid detection for tumor marker. The voltage and current resolution of portable device were 0.8 mV and 1 nA, respectively. Combined with laboratory made paper-based analytical device, carcinoembryonic antigen(CEA) was tested by portable device. Experimental results revealed that the DPV peak currents showed good linear relation with the logarithm of CEA concentration in the range from 1 μg/L to 500 μg/L. Its corresponding correlation coefficient was 0.998 and the limit of detection was 10 pg/mL. According to the principle of specific binding of antibody and antigen and electrochemical detection, CEA concentration could be calculated automatically according to the linear equation. The portable device had high sensitivity and low detection limit features which could be widely used in the point-of-care testing of tumor marker.
- Carcinoembryonic antigen,
- Electrochemical detection,
- Differential pulse voltammetry,
- Portable,
- Point-of-care testing
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