Citation: JIANG Qiu-Tao, ZENG Li, MA Jie, PENG Ling-Na, LI Wen-Li, DING Ye, LI Jie. Determination of Soluble Heavy Metals in Baizi Yangxin Tablets by Inductively Coupled Plasma Mass Spectrometry with Bionic Extraction and Microwave Digestion Technology[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(6): 979-983. doi: 10.11895/j.issn.0253-3820.150927 shu

Determination of Soluble Heavy Metals in Baizi Yangxin Tablets by Inductively Coupled Plasma Mass Spectrometry with Bionic Extraction and Microwave Digestion Technology

JIANG Qiu-Tao ^1, ,
ZENG Li ¹ ,
MA Jie ² ,
PENG Ling-Na ² ,
LI Wen-Li ² ,
DING Ye ² ,
LI Jie ¹

1.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
2.
Hunan Food and Drug Inspection Institute, Changsha 410001, China

Received Date: 17 November 2015
Revised Date: 4 January 2016

Fund Project: This work was supported by the National Ministry of Science and Technology (No. 2014 zx09304-307) and 2014 National Drug Sample Plan of CFDA.

Baizi Yangxin tablets are common Chinese medicine used for the treatment of heart palpitations, insomnia and irritable forgetful. To evaluate the total amount of heavy metals evaluation, artificial gastric juice was used as juice samples and the extracted soluble heavy metals were extracted by microwave digestion technology. An analytical method of bionic extraction microwave digestion with inductively coupled plasma mass spectrometry ( ICP-MS ) was established for the determination of trace metals, such as Co, Cr, Cu, Ba, Cd, Mn, Ni, Pb, Hg, Sr and Zn, in 18 batches of Baizi Yangxin tablets. The correlation coefficient of linear regression equation for different elements ranged from 0.9989 to 1.0000, the detection limit was 0.19-5.6 μg/L, and the repeatability of the method was less than 6.2%, the precision of the RSD value was less than 5.6%, and the recovery rate was 87.7%-101.9%. According to the standard of the heavy metal in the standard of import and export of medicinal plants and preparations, the contents of Cd, Cu and Pb in the 18 batches were not exceed the standard, but the Hg content (7.68 mg/kg) exceeded the standard value. The bionic extraction-ICP-MS method provide a reference basis for the safety of the proprietary Chinese medicine's study.
- Baizi Yangxin tablets,
- Cinnabar,
- Bionic extraction,
- Inductively coupled plasma mass spectrometry
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