Citation: ZOU Hai-Min, ZHOU Chen, YU Hui-Ju, ZHANG Qian, ZENG Hong-Yan, LI Yong-Xin. Simultaneous Determination of 16 Nitrobenzene Compounds in Drinking Water by Solid Phase Extraction-Gas Chromatography coupled with Electron Capture Detection[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(2): 297-304. doi: 10.11895/j.issn.0253-3820.150648 shu

Simultaneous Determination of 16 Nitrobenzene Compounds in Drinking Water by Solid Phase Extraction-Gas Chromatography coupled with Electron Capture Detection

1.
¹ Chengdu Center for Disease Control & Prevention, Chengdu 610047, China;
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² West China School of Public Health, Sichuan University, Chengdu 610041, China

Corresponding author: ZOU Hai-Min,
Received Date: 15 August 2015
Available Online: 22 October 2015
Fund Project: 本文系四川省科技支撑计划基金(No.2012SZ0196)资助项目 (No.2012SZ0196)

A solid phase extraction (SPE)-gas chromatography coupled with electron capture detection (GC-ECD) method was developed for the simultaneous determination of 16 nitrobenzene compounds in drinking water. The chromatographic conditions, i.e. the chromatographic column and the programmed temperature, were optimized, and the extraction conditions, i.e. the type of extraction column, elution solvent and volume of elution solvent, were also optimized. Water samples were extracted with Oasis HLB columns and eluted by the mixture of n-hexane and acetone (3:1, V/V). All the target compounds were chromatographically separated on a DB-1701 capillary column with programed temperature, and were detected by electron capture detector. The favorable resolutions of all target compounds were achieved within 33 min. Under the optimal analytical conditions, the peak area of each analyte and its concentration had a good correlation within the linear range (r≥0.998). The limit of detection (LOD) and limit of quantification (LOQ) of the method were 0.01-0.77 μg/L (S/N=3) and 0.03-2.57 μg/L (S/N=10), respectively. The intra- and inter-day relative standard deviations (RSDs) of the sample were 1.0%-3.8% and 2.3%-4.8%, respectively. Spiked recoveries of the analytes were 83.6%-111.8% and the RSDs of the spiked samples were 1.2%-5.1%. This proposed method has been applied in the detection of 50 water samples. The results indicated that the new solid phase extraction-gas chromatography coupled with electron capture detection method was specific, sensitive and reproducible, and could be used for the determination of 16 nitrobenzene compounds in drinking water.
- Gas chromatography,
- Solid phase extraction,
- Nitrobenzene,
- Drinking water
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