Citation: Xiaoyu YANG, Yejun ZHANG, Yu ZOU, Hongchao YANG, Jiang JIANG, Qiangbin WANG. Research progress of inorganic X-ray nanoscintillators[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(10): 1929-1952. doi: 10.11862/CJIC.20250122 shu

Research progress of inorganic X-ray nanoscintillators

Xiaoyu YANG ^{1, 2} ,
Yejun ZHANG ^1,, ,
Yu ZOU ^1,, ,
Hongchao YANG ¹ ,
Jiang JIANG ¹ ,
Qiangbin WANG ^{1, 2,,}

1.
CAS Key Laboratory of Nano⁃Bio Interface, Division of Nanobiomedicine and i⁃Lab, Suzhou Institute of Nano⁃Tech and Nano⁃Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China
2.
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China

Corresponding author: Yejun ZHANG, yjzhang2009@sinano.ac.cn Yu ZOU, yzou2012@sinano.ac.cn Qiangbin WANG, qbwang2008@sinano.ac.cn
Received Date: 8 April 2025
Revised Date: 9 June 2025

Figures(13)

Inorganic X-ray nanoscintillators have attracted considerable attention from researchers due to their outstanding optical properties and solution processability, offering promising prospects for applications in flexible scintillating screens, bioimaging, disease theranostics, and related fields. This review highlights recent advancements in inorganic X-ray nanoscintillators, focusing on transition metal ion-doped nanocrystals, quantum dots, clusters, and nanoscale metal-organic framework scintillator materials, along with their scintillation mechanisms. Additionally, the paper reviews the latest achievements in applying inorganic nanoscintillators to areas such as detection, information storage, bioimaging, and therapy. Finally, future development directions are discussed, emphasizing their enormous potential in three-dimensional flexible detectors and near-infrared Ⅱ fluorescence imaging.
- X-ray excited luminescence,
- nanoscintillators,
- nanomaterials,
- X-ray detetor,
- bioimaging
1. [1]
  XU S S, JIANG X L. X-ray wavelength standard[J]. Physics, 1974, 3(2): 108-112
2. [2]
  RÖNTGEN W C. On a new kind of rays[J]. Science, 1896, 3(59): 227-231 doi: 10.1126/science.3.59.227
3. [3]
  ZDESENKO Y G, AVIGNONE LⅡ F T, BRUDANIN V B, BRUDANIN, V B, DANEVICH F A, NAGORNY S S, SOLSKY I M, TRETYAK V I. Scintillation properties and radioactive contamination of CaWO₄ crystal scintillators[J]. Nucl. Instrum. Methods Phys. Res. Sect. A‒Accel. Spectrom. Dect. Assoc. Equip., 2005, 538(1/2/3): 657-667
4. [4]
  YASUDA K, USUDA S, GUNJI H. Simultaneous alpha, beta/gamma, and neutron counting with phoswich detectors by using a dual-parameter technique[J]. IEEE Trans. Nucl. Sci., 2001, 48(4): 1162-1164 doi: 10.1109/23.958743
5. [5]
  McELHANEY S, RAMSEY J, BAUER M, CHILES M. A ruggedized ZnS(Ag)/epoxy alpha scintillation detector[J]. Nucl. Instrum. Methods Phys. Res. Sect. A‒Accel. Spectrom. Dect. Assoc. Equip., 1990, 299(1/2/3): 111-114
6. [6]
  SHEPHERD J A, SOBOTTKA S E, WILLIAMS M B. Performance and fabrication of thin film NaI(Tl) scintillators for use on imaging photomultiplier tubes[J]. IEEE Trans. Nucl. Sci., 1993, 40(4): 413-416 doi: 10.1109/23.256591
7. [7]
  KUBOTA S, SHIRAISHI F, TAKAMI Y. Decay curves of NaI(Tl) scintillators with different Tl⁺ concentrations under excitation of electrons, alpha particles and fission fragments[J]. J. Phys. Soc. Jpn., 1999, 68(1): 291-297 doi: 10.1143/JPSJ.68.291
8. [8]
  WANG Z T, HAUSER N, SINGER G, TRIPPEL M, KUBIK-HUCH R A, SCHNEIDER C W, STAMPANONI M. Non-invasive classification of microcalcifications with phase-contrast X-ray mammography[J]. Nat. Commun., 2014, 5: 3797 doi: 10.1038/ncomms4797
9. [9]
  WANG G Y, LIU X H, SHEN J, WANG C D, LI Z H, YE L S, WU X W, CHEN T, WANG K, ZHANG X, ZHOU Z G, YANG J, SANG Y, DENG R Y, LIANG W H, YU T, GAO M, WANG J, YANG Z H, CAI H M, LU G M, ZHANG L Y, YANG L, XU W Q, WANG W, OLVERA A, ZIYAR I, ZHANG C, LI O L, LIAO W H, LIU J, CHEN W, CHEN W, SHI J C, ZHENG L H, ZHANG L J, YAN Z H, ZOU X G, LIN G P, CAO G Q, LAU L L, MO L, LIANG Y, ROBERTS M, SALA E, SCHöNLIEB C B, FOK M, LAU J Y N, XU T, HE J X, ZHANG K, LI W M, LIN T X. A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images[J]. Nat. Biomed. Eng., 2021, 5(6): 509-521 doi: 10.1038/s41551-021-00704-1
10. [10]
  MOMOSE A, TAKEDA T, ITAI Y, HIRANO K. Phase-contrast X-ray computed tomography for observing biological soft tissues[J]. Nat. Med., 1996, 2(4): 473-475 doi: 10.1038/nm0496-473
11. [11]
  RABIN O, MANUEL PEREZ J, GRIMM J, WOJTKIEWICZ G, WEISSLEDER R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles[J]. Nat. Mater., 2006, 5(2): 118-122 doi: 10.1038/nmat1571
12. [12]
  HOLL I, LORENZ E, MAGERAS G. A measurement of the light yield of common inorganic scintillators[J]. IEEE Trans. Nucl. Sci., 1988, 35(1): 105-109 doi: 10.1109/23.12684
13. [13]
  GRABMAIER B C. Crystal scintillators[J]. IEEE Trans. Nucl. Sci., 1984, 31(1): 372-376 doi: 10.1109/TNS.1984.4333280
14. [14]
  MELCHER C L, SCHWEITZER J S. Cerium-doped lutetium oxyorthosilicate‒A fast, efficient new scintillator[J]. IEEE Trans. Nucl. Sci., 1992, 39(4): 502-505 doi: 10.1109/23.159655
15. [15]
  WEBER M J, MONCHAMP R R. Luminescence of Bi₄Ge₃O₁₂: Spectral and decay properties[J]. J. Appl. Phys., 1973, 44(12): 5495-5499 doi: 10.1063/1.1662183
16. [16]
  LAVAL M, MOSZYŃSKI M, ALLEMAND R, CORMORECHE E, GUINET P, ODRU R, VACHER J. Barium fluoride-inorganic scintillator for subnanosecond timing[J]. Nucl. Instrum. Methods Phys. Res., 1983, 206(1/2): 169-176
17. [17]
  KIM Y K, KIM H K, CHO G, KIM D K. Effect of yttria substitution on the light output of (Gd, Y)₂O₃∶Eu ceramic scintillator[J]. Nucl. Instrum. Methods Phys. Res. Sect. B‒Beam Interact. Mater. Atoms, 2004, 225(3): 392-396 doi: 10.1016/j.nimb.2004.03.087
18. [18]
  CHEN Q W, SHI Y, SHI J L. The latest progress in ceramic scintillators research[J]. Journal Materials Science and Engineering, 2005, 23(1): 128-132
19. [19]
  KAMADA K, ENDO T, TSUTUMI K, YANAGIDA T, FUJIMOTO Y, FUKABORI A, YOSHIKAWA A, PEJCHAL J, NIKL M. Composition engineering in cerium-doped (Lu, Gd)₃(Ga, Al)₅O₁₂ single-crystal scintillators[J]. Cryst. Growth Des., 2011, 11(10): 4484-4490 doi: 10.1021/cg200694a
20. [20]
  JIANG M Y, DENG Z M, ZENG S J, HAO J H. Recent progress on lanthanide scintillators for soft X-ray-triggered bioimaging and deep-tissue theranostics[J]. View, 2021, 2(4): 20200122 doi: 10.1002/VIW.20200122
21. [21]
  RODNYI P A, DORENBOS P, EIJK C V. Energy loss in inorganic scintillators[J]. Phys. Status Solidi B, 1995, 18715-29
22. [22]
  WEBER M J. Scintillation: Mechanisms and new crystals[J]. Nucl. Instrum. Methods Phys. Res. Sect. A‒Accel. Spectrom. Dect. Assoc. Equip., 2004, 527(1): 9-14
23. [23]
  ZHOU Y, CHEN J, BAKR O M, MOHAMMED O F. Metal halide perovskites for X-ray imaging scintillators and detectors[J]. ACS Energy Lett., 2021, 6(2): 739-768 doi: 10.1021/acsenergylett.0c02430
24. [24]
  MADDALENA F, TJAHJANA L, XIE A, ARRAMEL, ZENG S W, WANG H, COQUET P, DROZDOWSKI W, DUJARDIN C, DANG C. Inorganic, organic, and perovskite halides with nanotechnology for high-light yield X- and γ-ray scintillators[J]. Crystals, 2019, 9(2): 88 doi: 10.3390/cryst9020088
25. [25]
  NIKL M. Scintillation detectors for X-rays[J]. Meas. Sci. Technol., 2006, 17(4): R37 doi: 10.1088/0957-0233/17/4/R01
26. [26]
  CHEN H Y, MOORE T, QI B, COLVIN D C, JELEN E K, HITCHCOCK D A, HE J, MEFFORD O T, GORE J C, ALEXIS F, ANKER J N. Monitoring pH-triggered drug release from radioluminescent nanocapsules with X-ray excited optical luminescence[J]. ACS Nano, 2013, 7(2): 1178-1187 doi: 10.1021/nn304369m
27. [27]
  MOORE T L, WANG F L, CHEN H Y, GRIMES S W, ANKER J N, ALEXIS F. Polymer-coated radioluminescent nanoparticles for quantitative imaging of drug delivery[J]. Adv. Funct. Mater., 2014, 24(37): 5815-5823 doi: 10.1002/adfm.201400949
28. [28]
  YOROV K E, NEMATULLOEV S, SAIDZHONOV B M, SKOROTETCKY M S, KARLUK A A, HASANOV B E, MIR W J, SHEIKH T, GUTIÉRREZ ARZALUZ L, PHIELEPEIT M E M, ASHRAF N, BLICK R H, MOHAMMED O F, BAYINDIR M, BAKR O M. Controlled synthesis of terbium-doped colloidal Gd₂O₂S nanoplatelets enables high-performance X-ray scintillators[J]. ACS Nano, 2024, 18(31): 20111-20122 doi: 10.1021/acsnano.4c01652
29. [29]
  SUN C, PRATX G, CARPENTER C M, LIU H G, CHENG Z, GAMBHIR S S, XING L. Synthesis and radioluminescence of pegylated Eu³⁺-doped nanophosphors as bioimaging probes[J]. Adv. Mater., 2011, 23(24): 201100919
30. [30]
  SUDHEENDRA L, DAS G K, LI C Q, STARK D, CENA J, CHERRY S, KENNEDY I M. NaGdF₄∶Eu³⁺ nanoparticles for enhanced X-ray excited optical imaging[J]. Chem. Mater., 2014, 26(5): 1881-1888 doi: 10.1021/cm404044n
31. [31]
  NACZYNSKI D J, SUN C, TÜRKCAN S, JENKINS C, KOH A L, IKEDA D, PRATX G, XING L. X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes[J]. Nano Lett., 2015, 15(1): 96-102 doi: 10.1021/nl504123r
32. [32]
  LIANG H Y, HONG Z Z, LI S H, SONG X R, ZHANG D, CHEN Q S, LI J, YANG H H. An activatable X-ray scintillating luminescent nanoprobe for early diagnosis and progression monitoring of thrombosis in live rat[J]. Adv. Funct. Mater., 2020, 31(5): 2006353
33. [33]
  HE L R, WANG L Y, YU X J, TANG Y Z, JIANG Z, YANG G L, LIU Z, LI W W. Full-course NIR-Ⅱ imaging-navigated fractionated photodynamic therapy of bladder tumours with X-ray-activated nanotransducers[J]. Nat. Commun., 2024, 15: 8240 doi: 10.1038/s41467-024-52607-9
34. [34]
  CUAU L, AKL P, GAUTHERON A, HOUMEAU A, CHAPUT F, YAROMINA A, DUBOIS L, LAMBIN P, KARPATI S, PAROLA S, REZAEIFAR B, LANGLOIS J B, SI-MOHAMED S A, MONTCEL B, DOUEK P, LEROUGE F. Surface modification effect on contrast agent efficiency for X-ray based spectral photon-counting scanner/luminescence imaging: From fundamental study to in vivo proof of concept[J]. Nanoscale, 2024, 16(6): 2931-2944 doi: 10.1039/D3NR03710J
35. [35]
  LI Y, GECEVICIUS M, QIU J. Long persistent phosphors-from fundamentals to applications[J]. Chem. Soc. Rev., 2016, 45(8): 2090-2136 doi: 10.1039/C5CS00582E
36. [36]
  ZHANG L W, SHEN R C, TAN J, YUAN Q. Influence of doped ions on persistent luminescence materials: A review[J]. Chin. J. Struct. Chem, 2022, 41(2): 2202148-2202158
37. [37]
  ZHENG B, FAN J, CHEN B, QIN X, WANG J, WANG F, DENG R, LIU X. Rare-earth doping in nanostructured inorganic materials[J]. Chem. Rev., 2022, 122(6): 5519-5603 doi: 10.1021/acs.chemrev.1c00644
38. [38]
  COOPER D R, CAPOBIANCO J A, SEUNTJENS J. Radioluminescence studies of colloidal oleate-capped β-Na(Gd, Lu)F₄∶Ln³⁺ nanoparticles (Ln=Ce, Eu, Tb)[J]. Nanoscale, 2018, 10(16): 7821-7832 doi: 10.1039/C8NR01262H
39. [39]
  OU X Y, QIN X, HUANG B L, ZAN J, WU Q X, HONG Z Z, XIE L L, BIAN H Y, YI Z G, CHEN X F, WU Y M, SONG X R, LI J, CHEN Q S, YANG H H, LIU X G. High-resolution X-ray luminescence extension imaging[J]. Nature, 2021, 590(7846): 410-415 doi: 10.1038/s41586-021-03251-6
40. [40]
  PEI P, CHEN Y, SUN C X, FAN Y, YANG Y M, LIU X, LU L F, ZHAO M Y, ZHANG H X, ZHAO D Y, LIU X G, ZHANG F. X-ray-activated persistent luminescence nanomaterials for NIR-Ⅱ imaging[J]. Nat. Nanotechnol., 2021, 16(9): 1011-1018 doi: 10.1038/s41565-021-00922-3
41. [41]
  ZHUANG Y X, CHEN D R, CHEN W J, ZHANG W X, SU X, DENG R R, AN Z F, CHEN H M, XIE R J. X-ray-charged bright persistent luminescence in NaYF₄∶Ln³⁺@NaYF₄ nanoparticles for multidimensional optical information storage[J]. Light‒Sci. Appl., 2021, 10: 132
42. [42]
  LEI L, WANG Y B, XU W X, YE R G, HUA Y J, DENG D G, CHEN L, PRASAD P N, XU S Q. Manipulation of time-dependent multicolour evolution of X-ray excited afterglow in lanthanide-doped fluoride nanoparticles[J]. Nat. Commun., 2022, 13: 5739 doi: 10.1038/s41467-022-33489-1
43. [43]
  XIE F, CHEN D X, ZHANG Y, LV X L, CHEN X, SUN K N, LIANG Y J. Colloidal KLu₃F₁₀∶Tb³⁺ persistent luminescence nanocrystal based flexible detectors for 3D X-ray imaging[J]. J. Mater. Chem. C, 2023, 11(47): 16772-16781 doi: 10.1039/D3TC03409G
44. [44]
  ZOU H R, ZHU W J, ZHAO J T, ZHOU S, XU S Q, LEI L. Sub-10 nm lanthanide-doped Lu₆O₅F₈ nanoscintillators for real-time high-resolution dynamic 3D X-ray imaging[J]. Adv. Funct. Mater., 2024, 34(49): 2409156 doi: 10.1002/adfm.202409156
45. [45]
  CHEN H M, WANG G D, CHUANG Y J, ZHEN Z P, CHEN X Y, BIDDINGER P, HAO Z L, LIU F, SHEN B Z, PAN Z W, XIE J. Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment[J]. Nano Lett., 2015, 15(4): 2249-2256 doi: 10.1021/nl504044p
46. [46]
  SONG L, LIN X H, SONG X R, CHEN S, CHEN X F, LI J, YANG H H. Repeatable deep-tissue activation of persistent luminescent nanoparticles by soft X-ray for high sensitivity long-term in vivo bioimaging[J]. Nanoscale, 2017, 9(8): 2718-2722 doi: 10.1039/C6NR09553D
47. [47]
  GUO T, LIN Y, ZHANG W J, HONG J S, LIN R H, WU X P, LI J, LU C H, YANG H H. High-efficiency X-ray luminescence in Eu³⁺-activated tungstate nanoprobes for optical imaging through energy transfer sensitization[J]. Nanoscale, 2018, 10(4): 1607-1612 doi: 10.1039/C7NR06405E
48. [48]
  ESPINOZA S, JUESTEL T, HAASE M. Colloidal LaPO₄∶Gd³⁺ nanocrystals: X-ray induced single line UV emission[J]. Nanoscale, 2018, 10(47): 22533-22540 doi: 10.1039/C8NR06867D
49. [49]
  BEKE D, NARDI M V, BORTEL G, TIMPEL M, CZIGÁNY Z, PASQUALI L, CHIAPPINI A, BAIS G, RUDOLF M, ZALKA D, BIGI F, ROSSI F, BENCS L, PEKKER A, MÁRKUS B G, SALVIATI G, SADDOW S E, KAMARÁS K, SIMON F, GALI A. Enhancement of X-ray-excited red luminescence of chromium-doped zinc gallate via ultrasmall silicon carbide nanocrystals[J]. Chem. Mater., 2021, 33(7): 2457-2465 doi: 10.1021/acs.chemmater.0c04671
50. [50]
  SHRIVASTAVA N, GUFFIE J, MOORE T L, GUZELTURK B, KUMBHAR A S, WEN J G, LUO Z P. Surface-doped zinc gallate colloidal nanoparticles exhibit pH-dependent radioluminescence with enhancement in acidic media[J]. Nano Lett., 2023, 23(14): 6482-6488 doi: 10.1021/acs.nanolett.3c01363
51. [51]
  XUE Z L, LI X L, LI Y B, JIANG M Y, LIU H N, ZENG S J, HAO J H. X-ray-activated near-infrared persistent luminescent probe for deep-tissue and renewable in vivo bioimaging[J]. ACS Appl. Mater. Interfaces, 2017, 9(27): 22132-22142 doi: 10.1021/acsami.7b03802
52. [52]
  CHEN Z Z, WANG L C, MANOHARAN D, LEE C L, WU L C, HUANG W T, HUANG E Y, SU C H, SHEU H S, YEH C S. Low dose of X-ray-excited long-lasting luminescent concave nanocubes in highly passive targeting deep-seated hepatic tumors[J]. Adv. Mater., 2019, 31(49): 1905087 doi: 10.1002/adma.201905087
53. [53]
  LIU B M, ZOU R, LOU S Q, GAO Y F, MA L, WONG K L, WANG J. Low-dose X-ray-stimulated LaGaO₃∶Sb, Cr near-infrared persistent luminescence nanoparticles for deep-tissue and renewable in vivo bioimaging[J]. Chem. Eng. J., 2021, 404127133
54. [54]
  YOROV K E, MIR W J, SONG X, GUTIÉRREZ ARZALUZ L, NAPHADE R, NEMATULLOEV S, CHEN C, HUANG R W, SHAO B Y, HASANOV B E, HAN Y, MOHAMMED O F, BAKR O M. Mn⁴⁺-doped fluoride nanocrystals enable high-resolution red-emitting X-ray imaging screens[J]. ACS Mater. Lett., 2022, 4(11): 2273-2281 doi: 10.1021/acsmaterialslett.2c00746
55. [55]
  BAWENDI M G, STEIGERWALD M L, BRUS L E. The quantum mechanics of larger semiconductor clusters ("quantum dots")[J]. Annu. Rev. Phys. Chem., 1990, 41(41): 477-496
56. [56]
  XU G X, ZENG S W, ZHANG B T, SWIHART M T, YONG K T, PRASAD P N. New generation cadmium-free quantum dots for biophotonics and nanomedicine[J]. Chem. Rev., 2016, 116(19): 12234-12327 doi: 10.1021/acs.chemrev.6b00290
57. [57]
  WEGNER K D, HILDEBRANDT N. Quantum dots: Bright and versatile in vitro and in vivo fluorescence imaging biosensors[J]. Chem. Soc. Rev., 2015, 44(14): 4792-4834 doi: 10.1039/C4CS00532E
58. [58]
  MARTYNENKO I V, LITVIN A P, PURCELL MILTON F, BARANOV A V, FEDOROV A V, GUN'KO Y K. Application of semiconductor quantum dots in bioimaging and biosensing[J]. J. Mater. Chem. B, 2017, 5(33): 6701-6727 doi: 10.1039/C7TB01425B
59. [59]
  YAO J, LI L, LI P F, YANG M. Quantum dots: From fluorescence to chemiluminescence, bioluminescence, electrochemiluminescence, and electrochemistry[J]. Nanoscale, 2017, 9(36): 13364-13383 doi: 10.1039/C7NR05233B
60. [60]
  KANG Z T, ZHANG Y L, MENKARA H, WAGNER B K, SUMMERS C J, LAWRENCE W, NAGARKAR V. CdTe quantum dots and polymer nanocomposites for X-ray scintillation and imaging[J]. Appl. Phys. Lett., 2011, 98(18): 181914 doi: 10.1063/1.3589366
61. [61]
  HOSSU M, LIU Z X, YAO M Z, MA L, CHEN W. X-ray luminescence of CdTe quantum dots in LaF₃∶Ce/CdTe nanocomposites[J]. Appl. Phys. Lett., 2012, 100(1): 103104
62. [62]
  GUIDELLI E J, LIGNOS I, YOO J J, LUSARDI M, BAWENDI M G, BAFFA O, JENSEN K F. Mechanistic insights and controlled synthesis of radioluminescent ZnSe quantum dots using a microfluidic reactor[J]. Chem. Mater., 2018, 30(23): 8562-8570 doi: 10.1021/acs.chemmater.8b03587
63. [63]
  CARULLI F, COVA F, GIRONI L, MEINARDI F, VEDDA A, BROVELLI S. Stokes shift engineered Mn∶CdZnS/ZnS nanocrystals as reabsorption-free nanoscintillators in high loading polymer composites[J]. Adv. Opt. Mater., 2022, 10(13): 202200419
64. [64]
  FANG Z H, TANG H T, YANG Z, ZHANG H, PENG Q P, YU X, ZHOU D C, QIU J B, XU X H. Transparent medium embedded with CdS quantum dots for X-ray imaging[J]. Adv. Opt. Mater., 2021, 9(24): 2101607 doi: 10.1002/adom.202101607
65. [65]
  CHEN Q S, WU J, OU X Y, HUANG B L, ALMUTLAQ J, ZHUMEKENOV A A, GUAN X W, HAN S Y, LIANG L L, YI Z G, LI J, XIE X J, WANG Y, LI Y, FAN D Y, TEH D B L, ALL A H, MOHAMMED O F, BAKR O M, WU T, BETTINELLI M, YANG H H, HUANG W, LIU X G. All-inorganic perovskite nanocrystal scintillators[J]. Nature, 2018, 561(7721): 88-93 doi: 10.1038/s41586-018-0451-1
66. [66]
  HEO J H, SHIN D H, PARK J K, KIM D H, LEE S J, IM S H. High-performance next-generation perovskite nanocrystal scintillator for nondestructive X-ray imaging[J]. Adv. Mater., 2018, 30(40): 1801743 doi: 10.1002/adma.201801743
67. [67]
  ZHANG Y H, SUN R J, OU X Y, FU K F, CHEN Q S, DING Y C, XU L J, LIU L M, HAN Y, MALKO A V, LIU X G, YANG H H, BAKR O M, LIU H, MOHAMMED O F. Metal halide perovskite nanosheet for X-ray high-resolution scintillation imaging screens[J]. ACS Nano, 2019, 13(2): 2520-2525 doi: 10.1021/acsnano.8b09484
68. [68]
  LI Y W, XU Y L, YAO F, LIN Q Q. Heterovalent cation-exchange of CsPbBr₃ perovskite nanocrystals with enhanced stability for X-ray imaging[J]. Appl. Phys. Lett., 2023, 123(11): 111103 doi: 10.1063/5.0158665
69. [69]
  YANG Z, YAO J S, XU L M, FAN W X, SONG J Z. Designer bright and fast CsPbBr₃ perovskite nanocrystal scintillators for high-speed X-ray imaging[J]. Nat. Commun., 2024, 15: 8870 doi: 10.1038/s41467-024-53263-9
70. [70]
  WANG Y, WANG C, MEN L, HU Q S, XIAO J W. Colloidal synthesis of hollow double perovskite nanocrystals and their applications in X-ray imaging[J]. Inorg. Chem., 2024, 63(12): 5734-5742 doi: 10.1021/acs.inorgchem.4c00280
71. [71]
  XING G Y, CUI E D, YUAN X Y, WANG B, ZHAO Y A, TANG J F, CHEN J C, LIU J. Defects in ligand-exchange-passivated mixed- halide double perovskite nanocrystals for X-ray imaging[J]. Laser Photon. Rev., 2025, 19(5): 2401552 doi: 10.1002/lpor.202401552
72. [72]
  GUAN L Q, SHI S, NIU X W, GUO S C, ZHAO J, JI T M, DONG H, JIA F Y, XIAO J W, SUN L D, YAN C H. All-inorganic manganese-based CsMnCl₃ nanocrystals for X-ray imaging[J]. Adv. Sci., 2022, 9(18): 202201354
73. [73]
  ZHOU J E, AN K, HE P, YANG J, ZHOU C, LUO Y, KANG W, HU W, FENG P, ZHOU M, TANG X S. Solution-processed lead-free perovskite nanocrystal scintillators for high-resolution X-ray CT imaging[J]. Adv. Opt. Mater., 2021, 9(11): 2022144
74. [74]
  YAO Q F, ZHU M S Q, YANG Z C, SONG X R, YUAN X, ZHANG Z P, HU W P, XIE J P. Molecule-like synthesis of ligand-protected metal nanoclusters [J]. Nat. Rev. Mater., 2025, 10(2): 89-108
75. [75]
  WANG J J, FENG L Z, SHI G Y, YANG J N, ZHANG Y D, XU H Y, SONG K H, CHEN T, ZHANG G Z, ZHENG X S, FAN F J, XIAO Z G, YAO H B. High efficiency warm-white light-emitting diodes based on copper-iodide clusters[J]. Nat. Photonics, 2024, 18(2): 200-206 doi: 10.1038/s41566-023-01340-8
76. [76]
  ZHANG N, LI Y, HAN S Y, WEI Y, HU H, HUO R, DUAN C B, ZHANG J, HAN C M, XIE G H, XU H. Cluster light-emitting diodes containing copper iodine cube with 100% exciton utilization using host-cluster synergy[J]. Angew. Chem. ‒Int. Edit., 2023, 62(27): e202305018 doi: 10.1002/anie.202305018
77. [77]
  OSAKADA Y, PRATX G, SUN C, SAKAMOTO M, AHMAD M, VOLOTSKOVA O, ONG Q X, TERANISHI T, HARADA Y, XING L, CUI B X. Hard X-ray-induced optical luminescence via biomolecule-directed metal clusters[J]. Chem. Commun., 2014, 50(27): 3549-3551 doi: 10.1039/C3CC48661C
78. [78]
  LIU Z Y, JUNG K O, TAKAHATA R, SAKAMOTO M, TERANISHI T, FUJITSUKA M, PRATX G, OSAKADA Y. Hard X-ray excited optical luminescence from protein-directed Au_∼20 clusters[J]. RSC Adv., 2020, 10(23): 13824-13829 doi: 10.1039/D0RA01935F
79. [79]
  KIRAKCI K, KUBáT P, FEJFAROVá K, MARTINČíK J, NIKL M, LANG K. X-ray inducible luminescence and singlet oxygen sensitization by an octahedral molybdenum cluster compound: A new class of nanoscintillators [J]. Inorg. Chem., 2015, 55(2): 803-809
80. [80]
  EVTUSHOK D V, MELNIKOV A R, VOROTNIKOVA N A, VOROTNIKOV Y A, RYADUN A A, KURATIEVA N V, KOZYR K V, OBEDINSKAYA N R, KRETOV E I, NOVOZHILOV I N, MIRONOV Y V, STASS D V, EFREMOVA O A, SHESTOPALOV M A. A comparative study of optical properties and X-ray induced luminescence of octahedral molybdenum and tungsten cluster complexes[J]. Dalton Trans., 2017, 46(35): 11738-11747 doi: 10.1039/C7DT01919J
81. [81]
  KIRAKCI K, FEJFAROVÁ K, MARTINČÍK J, NIKL M, LANG K. Tetranuclear copper(Ⅰ) iodide complexes: A new class of X-ray phosphors[J]. Inorg. Chem., 2017, 56(8): 4609-4614 doi: 10.1021/acs.inorgchem.7b00240
82. [82]
  ZHOU Y, HE T Y, YUAN P, YIN J, CHEN S L, GUTIÉRREZ ARZALUZ L, WANG L J, BAKR O M, MOHAMMED O F. Colloidal Cu₄I₄ clusters for high-resolution X-ray imaging scintillation screens[J]. ACS Mater. Lett., 2023, 5(8): 2002-2008 doi: 10.1021/acsmaterialslett.3c00377
83. [83]
  LU K D, AUNG T, GUO N N, WEICHSELBAUM R, LIN W B. Nanoscale metal-organic frameworks for therapeutic, imaging, and sensing applications[J]. Adv. Mater., 2018, 30(37): 1707634 doi: 10.1002/adma.201707634
84. [84]
  WU M X, YANG Y W. Metal-organic framework (MOF)-based drug/cargo delivery and cancer therapy[J]. Adv. Mater., 2017, 29(23): 1606134 doi: 10.1002/adma.201606134
85. [85]
  HE C B, LIU D M, LIN W B. Nanomedicine applications of hybrid nanomaterials built from metal-ligand coordination bonds: Nanoscale metal-organic frameworks and nanoscale coordination polymers[J]. Chem. Rev., 2015, 115(19): 11079-11108 doi: 10.1021/acs.chemrev.5b00125
86. [86]
  LAN G X, NI K Y, XU R Y, LU K D, LIN Z K, CHAN C, LIN W B. Nanoscale metal-organic layers for deeply penetrating X‑ray‑induced photodynamic therapy[J]. Angew. Chem. ‒Int. Edit., 2017, 56(40): 12102-12106 doi: 10.1002/anie.201704828
87. [87]
  WANG C, VOLOTSKOVA O, LU K D, AHMAD M, SUN C, XING L, LIN W B. Synergistic assembly of heavy metal clusters and luminescent organic bridging ligands in metal-organic frameworks for highly efficient X-ray scintillation[J]. J. Am. Chem. Soc., 2014, 136(17): 6171-6174 doi: 10.1021/ja500671h
88. [88]
  PEREGO J, VILLA I, PEDRINI A, PADOVANI E C, CRAPANZANO R, VEDDA A, DUJARDIN C, BEZUIDENHOUT C X, BRACCO S, SOZZANI P E, COMOTTI A, GIRONI L, BERETTA M, SALOMONI M, KRATOCHWIL N, GUNDACKER S, AUFFRAY E, MEINARDI F, MONGUZZI A. Composite fast scintillators based on high-Z fluorescent metal-organic framework nanocrystals[J]. Nat. Photonics, 2021, 15(5): 393-400 doi: 10.1038/s41566-021-00769-z
89. [89]
  PEREGO J, BEZUIDENHOUT C X, VILLA I, COVA F, CRAPANZANO R, FRANK I, PAGANO F, KRATOCHWILL N, AUFFRAY E, BRACCO S, VEDDA A, DUJARDIN C, SOZZANI P E, MEINARDI F, COMOTTI A, MONGUZZI A. Highly luminescent scintillating hetero-ligand MOF nanocrystals with engineered Stokes shift for photonic applications[J]. Nat. Commun., 2022, 13: 3504 doi: 10.1038/s41467-022-31163-0
90. [90]
  WANG F, DENG R R, LIU X G. Preparation of core-shell NaGdF₄ nanoparticles doped with luminescent lanthanide ions to be used as upconversion-based probes[J]. Nat. Protoc., 2014, 9(7): 1634-1644 doi: 10.1038/nprot.2014.111
91. [91]
  CHEN G Y, OHULCHANSKYY T Y, LIU S, LAW W C, WU F, SWIHART M T, ÅGREN H, PRASAD P N. Core/shell NaGdF₄∶Nd³⁺/NaGdF₄ nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications[J]. ACS Nano, 2012, 6(4): 2969-2977 doi: 10.1021/nn2042362
92. [92]
  ZHU W J, MA W B, SU Y R, CHEN Z, CHEN X Y, MA Y G, BAI L Z, XIAO W G, LIU T Y, ZHU H M, LIU X F, LIU H F, LIU X, YANG Y. Low-dose real-time X-ray imaging with nontoxic double perovskite scintillators[J]. Light‒Sci. Appl., 2020, 9(1): 112
93. [93]
  ZHOU J, ZHU X J, CHEN M, SUN Y, LI F Y. Water-stable NaLuF₄-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging[J]. Biomaterials, 2012, 33(26): 6201-6210 doi: 10.1016/j.biomaterials.2012.05.036
94. [94]
  JIANG M Y, XUE Z L, LI Y B, LIU H R, ZENG S J, HAO J H. A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy[J]. Nanoscale Horiz., 2020, 5(2): 268-273 doi: 10.1039/C9NH00564A
95. [95]
  JIA T, XU J T, DONG S M, HE F, ZHONG C N, YANG G X, BI H T, XU M S, HU Y K, YANG D. Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging[J]. Chem. Sci., 2019, 10(37): 8618-8633 doi: 10.1039/C9SC01615E
96. [96]
  DAI Y, YANG D P, YU D P, CAO C, WANG Q H, XIE S H, SHEN L, FENG W, LI F Y. Mussel-inspired polydopamine-coated lanthanide nanoparticles for NIR-Ⅱ/CT dual imaging and photothermal therapy[J]. ACS Appl. Mater. Interfaces, 2017, 9(32): 26674-26683 doi: 10.1021/acsami.7b06109
97. [97]
  HOU B, YI L Y, HU D H, LUO Z C, GAO D Y, LI C, XING B W, WANG J W, LEE C N, ZHANG R, SHENG Z H, ZHOU B, LIU X G. A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy[J]. Nat. Biomed. Eng., 2023, 7(10): 1242-1251 doi: 10.1038/s41551-023-01024-2
98. [98]
  WIBOWO A, SHEIKH M A K, DIGUNA L J, ANANDA M B, MARSUDI M A, ARRAMEL A, ZENG S W, WONG L J, BIROWOSUTO M D. Development and challenges in perovskite scintillators for high-resolution imaging and timing applications[J]. Commun. Mater., 2023, 4(1): 21 doi: 10.1038/s43246-023-00348-5
99. [99]
  YI L Y, HOU B, ZHAO H, LIU X G. X-ray-to-visible light-field detection through pixelated colour conversion[J]. Nature, 2023, 618(7964): 281-286 doi: 10.1038/s41586-023-05978-w
100. [100]
  YANG Z J, ZHANG P, CHEN X F, HONG Z Z, GONG J W, OU X Y, WU Q X, LI W H, WANG X Z, XIE L L, ZHANG Z Z, YU Z Y, QIN X, TANG J, ZHANG H J, CHEN Q S, HAN S Y, YANG H H. High-confidentiality X-ray imaging encryption using prolonged imperceptible radioluminescence memory scintillators[J]. Adv. Mater., 2023, 35(52): 2309413 doi: 10.1002/adma.202309413
101. [101]
  ZHAO X T, LI Y B, DU L M, DENG Z M, JIANG M Y, ZENG S J. Soft X-ray stimulated lanthanide@MOF nanoprobe for amplifying deep tissue synergistic photodynamic and antitumor immunotherapy[J]. Adv. Healthcare Mater., 2021, 10(21): 2101174 doi: 10.1002/adhm.202101174
102. [102]
  MA X Q, LIN N, YANG Q, LIU P F, DING H Z, XU M J, REN F F, SHEN Z Y, HU K, MENG S S, CHEN H M. Biodegradable copper-iodide clusters modulate mitochondrial function and suppress tumor growth under ultralow‑dose X‑ray irradiation[J]. Nat. Commun., 2024, 15(1): 8092 doi: 10.1038/s41467-024-52278-6
103. [103]
  YANG K D, YANG Y T, SUN D Q, LI S H, SONG X R, YANG H H. Designing highly UV-emitting lanthanide nanoscintillators for in vivo X-ray-activated tumor therapy[J]. Sci. China Mater., 2023, 66(10): 4090-4099 doi: 10.1007/s40843-023-2548-8
104. [104]
  DU Z, WANG X, ZHANG X, GU Z J, FU X Y, GAN S J, FU T, XIE S T, TAN W H. X-ray-triggered carbon monoxide and manganese dioxide generation based on scintillating nanoparticles for cascade cancer radiosensitization[J]. Angew. Chem. ‒Int. Edit., 2023, 62(23): e202302525 doi: 10.1002/anie.202302525
105. [105]
  LIU S K, LI W T, CHEN H X, ZHOU J L, DONG S M, ZANG P Y, TIAN B S, DING H, GAI S L, YANG P P, ZHAO Y L. On-demand generation of peroxynitrite from an integrated two-dimensional system for enhanced tumor therapy[J]. ACS Nano, 2022, 16(6): 8939-8953 doi: 10.1021/acsnano.1c11422
106. [106]
  CHEN Z W, TSYTSAREV V, FINFROCK Y Z, ANTIPOVA O A, CAI Z H, ARAKAWA H, LISCHKA F W, HOOKS B M, WILTON R, WANG D Y, LIU Y, GAITAN B, TAO Y, CHEN Y, ERZURUMLU R S, YANG H H, ROZHKOVA E A. Wireless optogenetic modulation of cortical neurons enabled by radioluminescent nanoparticles[J]. ACS Nano, 2021, 15(3): 5201-5208 doi: 10.1021/acsnano.0c10436
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