Citation: Rui TIAN, Jiamin CHAI, Junyu CHEN, Yuan REN, Xuehua SUN, Haoyu LI, Yuecheng ZHANG. Chitosan/silica-coated copper nanoclusters: Synthesis and application in cefixime detection[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(9): 1903-1915. doi: 10.11862/CJIC.20250026 shu

Chitosan/silica-coated copper nanoclusters: Synthesis and application in cefixime detection

Rui TIAN ^{1, 2,,} ,
Jiamin CHAI ¹ ,
Junyu CHEN ¹ ,
Yuan REN ¹ ,
Xuehua SUN ^{1, 2} ,
Haoyu LI ¹ ,
Yuecheng ZHANG ¹

1.
Collage of Chemistry and Chemical Engineering, Yan′an University, Yan′an, Shaanxi 716000, China
2.
Yan′an Key Laboratory of Green Synthetic Materials and Chemical Safety Testing, Yan′an, Shaanxi 716000, China

Corresponding author: Rui TIAN, tianrui100@163.com
Received Date: 21 January 2025
Revised Date: 9 July 2025

Figures(9)

Herein, copper nanoclusters (Cu NCs) were synthesized in aqueous solution through a chemical reduction method using polyethyleneimine as reducing agent and protective ligand, with Cu(NO₃)₂ as copper source. Subsequently, composite fluorescent nanoparticles, chitosan-functionalized silica nanoparticles (CSNPs)-coated Cu NCs (Cu NCs/CSNPs), were synthesized via a reverse microemulsion method. Compared with Cu NCs, the composite Cu NCs/CSNPs exhibited an increased quantum yield and enhanced fluorescence sensing performance. Based on the composite Cu NCs/CSNPs, a fluorescence method for the detection of cefixime fluorescence quenching was established. The technique was simple, sensitive, and selective for detecting cefixime. The fluorescence quenching efficiency of Cu NCs/CSNPs was linearly related to the concentration of cefixime in the range of 3.98-38.5 μmol·L^-1 (1.81-17.46 mg·L^-1), with a limit of detection of 0.045 5 μmol·L^-1 (20.6 μg·L^-1).
- copper nanoclusters,
- fluorescence detection,
- cefixime
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沈阳化工大学材料科学与工程学院沈阳 110142